Structural alterations of the EGFR gene in glioblastoma samples as a prognostic factor and molecular target for therapy

Structural alterations of the EGFR gene in glioblastoma samples as a prognostic factor and molecular target for therapy

Introduction. Epidermal growth factor receptor (EGFR) is a transmembrane protein of the receptor tyrosine kinase family that is activated in various cancers (non-small cell lung cancer, colorectal cancer, head and neck tumors). In glial brain tumors, increased EGFR expression levels are characterist...

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Main Authors: V. O.  Varachev, O. Yu. Susova, A. A. Mitrofanov, G. S. Krasnov, D. R. Naskhletashvili, Yu. I.  Ammour, S. D. Bezhanova, N. V. Sevyan, E. V. Prozorenko, A. Kh. Bekyashev, T. V. Nasedkina
Format: Article
Language:Russian
Published: ABV-press 2024-10-01
Series:Успехи молекулярной онкологии
Subjects:
egfr gene
egfr gene amplification
mutation
egfrviii transcript
glioblastoma
next-generation sequencing
recurrent tumor
Online Access:https://umo.abvpress.ru/jour/article/view/709
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