Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination?
Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing...
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| Language: | English |
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Mary Ann Liebert
2024-04-01
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| Series: | Women's Health Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/whr.2024.0056 |
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| author | Isabelle C. Band Samantha L. Estevez Joseph A. Lee Morgan Baird Noah Copperman Daniel Stein Tanmoy Mukherjee Alan B. Copperman Jenna Friedenthal |
| author_facet | Isabelle C. Band Samantha L. Estevez Joseph A. Lee Morgan Baird Noah Copperman Daniel Stein Tanmoy Mukherjee Alan B. Copperman Jenna Friedenthal |
| author_sort | Isabelle C. Band |
| collection | DOAJ |
| description | Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing donor sperm IUI from January 2004 to April 2022. Cases included patients with MLP evaluation; controls included those without. MLP was obtained ∼7 days after ovulation. Only natural cycles with human chorionic gonadotropin trigger for timing were included. Primary outcome was clinical pregnancy rate; secondary outcomes were ongoing pregnancy (OP) and spontaneous abortion rates. Results: The study included 912 cycles, in 56 of which MLP was assessed. There were no demographic differences between groups. Among those assessed, the mean MLP was 10.96 ng/mL and 19/56 (33.9%) subsequently received supplemental progesterone. In an unadjusted analysis, there were no significant differences in clinical outcomes between groups. After adjusting for age, body mass index, day 3 follicle-stimulating hormone, and endometrial thickness at the time of ovulation, having MLP evaluated did not predict clinical (odds ratio [OR]: 3.34, confidence interval [CI]: 0.194–57.510, p = 0.406) or OP rate (OR 5.056, CI 0.24–106.62, p = 0.298). A subanalysis found no difference in clinical and OP rates when comparing patients who had received supplemental progesterone versus those who had not. Conclusion: Clinicians may reconsider the MLP assessment within same-sex female couples who use donor sperm IUI, as it does not appear to enhance treatment outcome. Prospective studies may delineate the cost–benefit analysis of the MLP assessment in this cohort. |
| format | Article |
| id | doaj-art-c745e68318fd413bbe6a6269cbb55922 |
| institution | OA Journals |
| issn | 2688-4844 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Women's Health Reports |
| spelling | doaj-art-c745e68318fd413bbe6a6269cbb559222025-08-20T02:30:55ZengMary Ann LiebertWomen's Health Reports2688-48442024-04-015196597210.1089/whr.2024.0056Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination?Isabelle C. Band0Samantha L. Estevez1Joseph A. Lee2Morgan Baird3Noah Copperman4Daniel Stein5Tanmoy Mukherjee6Alan B. Copperman7Jenna Friedenthal8Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Reproductive Medicine Associates of New York, New York, New York, USA.Reproductive Medicine Associates of New York, New York, New York, USA.Reproductive Medicine Associates of New York, New York, New York, USA.Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing donor sperm IUI from January 2004 to April 2022. Cases included patients with MLP evaluation; controls included those without. MLP was obtained ∼7 days after ovulation. Only natural cycles with human chorionic gonadotropin trigger for timing were included. Primary outcome was clinical pregnancy rate; secondary outcomes were ongoing pregnancy (OP) and spontaneous abortion rates. Results: The study included 912 cycles, in 56 of which MLP was assessed. There were no demographic differences between groups. Among those assessed, the mean MLP was 10.96 ng/mL and 19/56 (33.9%) subsequently received supplemental progesterone. In an unadjusted analysis, there were no significant differences in clinical outcomes between groups. After adjusting for age, body mass index, day 3 follicle-stimulating hormone, and endometrial thickness at the time of ovulation, having MLP evaluated did not predict clinical (odds ratio [OR]: 3.34, confidence interval [CI]: 0.194–57.510, p = 0.406) or OP rate (OR 5.056, CI 0.24–106.62, p = 0.298). A subanalysis found no difference in clinical and OP rates when comparing patients who had received supplemental progesterone versus those who had not. Conclusion: Clinicians may reconsider the MLP assessment within same-sex female couples who use donor sperm IUI, as it does not appear to enhance treatment outcome. Prospective studies may delineate the cost–benefit analysis of the MLP assessment in this cohort.https://www.liebertpub.com/doi/10.1089/whr.2024.0056mid-luteal progesteronesame-sex female couplesintrauterine inseminationmedicalizationlesbian |
| spellingShingle | Isabelle C. Band Samantha L. Estevez Joseph A. Lee Morgan Baird Noah Copperman Daniel Stein Tanmoy Mukherjee Alan B. Copperman Jenna Friedenthal Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? Women's Health Reports mid-luteal progesterone same-sex female couples intrauterine insemination medicalization lesbian |
| title | Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? |
| title_full | Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? |
| title_fullStr | Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? |
| title_full_unstemmed | Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? |
| title_short | Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination? |
| title_sort | is there clinical value in the mid luteal progesterone check in same sex female couples undergoing donor sperm intrauterine insemination |
| topic | mid-luteal progesterone same-sex female couples intrauterine insemination medicalization lesbian |
| url | https://www.liebertpub.com/doi/10.1089/whr.2024.0056 |
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