Is There Clinical Value in the Mid-Luteal Progesterone Check in Same-Sex Female Couples Undergoing Donor Sperm Intrauterine Insemination?
Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mary Ann Liebert
2024-04-01
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| Series: | Women's Health Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/10.1089/whr.2024.0056 |
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| Summary: | Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing donor sperm IUI from January 2004 to April 2022. Cases included patients with MLP evaluation; controls included those without. MLP was obtained ∼7 days after ovulation. Only natural cycles with human chorionic gonadotropin trigger for timing were included. Primary outcome was clinical pregnancy rate; secondary outcomes were ongoing pregnancy (OP) and spontaneous abortion rates. Results: The study included 912 cycles, in 56 of which MLP was assessed. There were no demographic differences between groups. Among those assessed, the mean MLP was 10.96 ng/mL and 19/56 (33.9%) subsequently received supplemental progesterone. In an unadjusted analysis, there were no significant differences in clinical outcomes between groups. After adjusting for age, body mass index, day 3 follicle-stimulating hormone, and endometrial thickness at the time of ovulation, having MLP evaluated did not predict clinical (odds ratio [OR]: 3.34, confidence interval [CI]: 0.194–57.510, p = 0.406) or OP rate (OR 5.056, CI 0.24–106.62, p = 0.298). A subanalysis found no difference in clinical and OP rates when comparing patients who had received supplemental progesterone versus those who had not. Conclusion: Clinicians may reconsider the MLP assessment within same-sex female couples who use donor sperm IUI, as it does not appear to enhance treatment outcome. Prospective studies may delineate the cost–benefit analysis of the MLP assessment in this cohort. |
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| ISSN: | 2688-4844 |