Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis

Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targ...

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Main Authors: Francesca Wright, Simiao Wu, Ho-Yan Yvonne Chun, Gillian Mead
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Stroke Research and Treatment
Online Access:http://dx.doi.org/10.1155/2017/2124743
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author Francesca Wright
Simiao Wu
Ho-Yan Yvonne Chun
Gillian Mead
author_facet Francesca Wright
Simiao Wu
Ho-Yan Yvonne Chun
Gillian Mead
author_sort Francesca Wright
collection DOAJ
description Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014. Study quality was assessed using an internationally endorsed checklist. We used odds ratios (ORs) to estimate the strength of associations and random-effects modelling to calculate summary effect sizes. Results. There were 24 studies recruiting 15448 patients. Quality of reporting was satisfactory. 13 studies with 2408 patients reported associations between poststroke anxiety and poststroke depression (OR=4.66, 95% confidence interval: 2.23, 9.74). One study reported association with prestroke anxiety, three with prestroke depression, one with fatigue, and two with sleep. No studies reported on locus of control, coping, or confidence. Conclusion. Poststroke anxiety was associated with depression but there are limited data on other modifiable associations. Further research is needed to identify potential targets for treatment.
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spelling doaj-art-c73f8db4b6c344ba8f63aec6b447c2ba2025-08-20T03:22:58ZengWileyStroke Research and Treatment2090-81052042-00562017-01-01201710.1155/2017/21247432124743Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-AnalysisFrancesca Wright0Simiao Wu1Ho-Yan Yvonne Chun2Gillian Mead3University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKBackground and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014. Study quality was assessed using an internationally endorsed checklist. We used odds ratios (ORs) to estimate the strength of associations and random-effects modelling to calculate summary effect sizes. Results. There were 24 studies recruiting 15448 patients. Quality of reporting was satisfactory. 13 studies with 2408 patients reported associations between poststroke anxiety and poststroke depression (OR=4.66, 95% confidence interval: 2.23, 9.74). One study reported association with prestroke anxiety, three with prestroke depression, one with fatigue, and two with sleep. No studies reported on locus of control, coping, or confidence. Conclusion. Poststroke anxiety was associated with depression but there are limited data on other modifiable associations. Further research is needed to identify potential targets for treatment.http://dx.doi.org/10.1155/2017/2124743
spellingShingle Francesca Wright
Simiao Wu
Ho-Yan Yvonne Chun
Gillian Mead
Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
Stroke Research and Treatment
title Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
title_full Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
title_fullStr Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
title_full_unstemmed Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
title_short Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis
title_sort factors associated with poststroke anxiety a systematic review and meta analysis
url http://dx.doi.org/10.1155/2017/2124743
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AT hoyanyvonnechun factorsassociatedwithpoststrokeanxietyasystematicreviewandmetaanalysis
AT gillianmead factorsassociatedwithpoststrokeanxietyasystematicreviewandmetaanalysis