GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites
As the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion of women at childbearing age. Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. In the...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/1484321 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565673878880256 |
|---|---|
| author | Zhihua Sun Peiyi Li Xiao Wang Shuchang Lai Hong Qiu Zhi Chen Shidi Hu Jie Yao Jie Shen |
| author_facet | Zhihua Sun Peiyi Li Xiao Wang Shuchang Lai Hong Qiu Zhi Chen Shidi Hu Jie Yao Jie Shen |
| author_sort | Zhihua Sun |
| collection | DOAJ |
| description | As the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion of women at childbearing age. Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. In the present study, we identified that, both in vivo and in vitro, GLP-1 functioned as the regulator of proliferation and antiapoptosis of MGCs of follicle in PCOS mouse ovary. Furthermore, forkhead box protein O1 (FoxO1) plays an important role in the courses. Regarding the importance of granulosa cells (GCs) in oocyte development and function, the results from the current study could provide a more detailed illustration on the already known beneficial effects of GLP-1RAs on PCOS and support the future efforts to develop more efficient GLP-1RAs for PCOS treatment. |
| format | Article |
| id | doaj-art-c73be74c63e443d2ae244d7756112104 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c73be74c63e443d2ae244d77561121042025-02-03T01:07:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/14843211484321GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation SitesZhihua Sun0Peiyi Li1Xiao Wang2Shuchang Lai3Hong Qiu4Zhi Chen5Shidi Hu6Jie Yao7Jie Shen8Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaMedical Research Center, Shunde Hospital of Southern Medical University, Shunde, Guangdong, ChinaEndocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaAs the major cause of female anovulatory infertility, polycystic ovary syndrome (PCOS) affects a great proportion of women at childbearing age. Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. In the present study, we identified that, both in vivo and in vitro, GLP-1 functioned as the regulator of proliferation and antiapoptosis of MGCs of follicle in PCOS mouse ovary. Furthermore, forkhead box protein O1 (FoxO1) plays an important role in the courses. Regarding the importance of granulosa cells (GCs) in oocyte development and function, the results from the current study could provide a more detailed illustration on the already known beneficial effects of GLP-1RAs on PCOS and support the future efforts to develop more efficient GLP-1RAs for PCOS treatment.http://dx.doi.org/10.1155/2020/1484321 |
| spellingShingle | Zhihua Sun Peiyi Li Xiao Wang Shuchang Lai Hong Qiu Zhi Chen Shidi Hu Jie Yao Jie Shen GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites International Journal of Endocrinology |
| title | GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites |
| title_full | GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites |
| title_fullStr | GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites |
| title_full_unstemmed | GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites |
| title_short | GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites |
| title_sort | glp 1 glp 1r signaling regulates ovarian pcos associated granulosa cells proliferation and antiapoptosis by modification of forkhead box protein o1 phosphorylation sites |
| url | http://dx.doi.org/10.1155/2020/1484321 |
| work_keys_str_mv | AT zhihuasun glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT peiyili glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT xiaowang glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT shuchanglai glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT hongqiu glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT zhichen glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT shidihu glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT jieyao glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites AT jieshen glp1glp1rsignalingregulatesovarianpcosassociatedgranulosacellsproliferationandantiapoptosisbymodificationofforkheadboxproteino1phosphorylationsites |