Major depressive disorder and the microbiome-gut-brain axis
The central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as de...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2025-04-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2025/05/Ouriaghli_97_2.pdf |
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| author | F. H. Ouriaghli I. A. Elhaty |
| author_facet | F. H. Ouriaghli I. A. Elhaty |
| author_sort | F. H. Ouriaghli |
| collection | DOAJ |
| description | The central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as depression and anxiety. This review aims to analyze how microbiota imbalances can affect the functioning of the gut-brain axis, causing changes in metabolism, immune system and neurotransmitters that are associated with depression. The potential of dietary modifications, probiotics, prebiotics and symbiotics to restore microbiota balance as well as the importance of microbiota profiling integration into personalized clinical practice are discussed. |
| format | Article |
| id | doaj-art-c73241f175814752a67eeea32ea0e576 |
| institution | Kabale University |
| issn | 2409-4943 2413-5003 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj-art-c73241f175814752a67eeea32ea0e5762025-08-20T03:30:24ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032025-04-01972133010.15407/ubj97.02.013Major depressive disorder and the microbiome-gut-brain axisF. H. Ouriaghli0I. A. Elhaty1https://orcid.org/0000-0003-4492-2181Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, TürkiyeDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, TürkiyeThe central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as depression and anxiety. This review aims to analyze how microbiota imbalances can affect the functioning of the gut-brain axis, causing changes in metabolism, immune system and neurotransmitters that are associated with depression. The potential of dietary modifications, probiotics, prebiotics and symbiotics to restore microbiota balance as well as the importance of microbiota profiling integration into personalized clinical practice are discussed.http://ukrbiochemjournal.org/wp-content/uploads/2025/05/Ouriaghli_97_2.pdfdietary patternmajor depressive disordermicrobiota-gut-brain axispersonalized treatmentprobiotics |
| spellingShingle | F. H. Ouriaghli I. A. Elhaty Major depressive disorder and the microbiome-gut-brain axis The Ukrainian Biochemical Journal dietary pattern major depressive disorder microbiota-gut-brain axis personalized treatment probiotics |
| title | Major depressive disorder and the microbiome-gut-brain axis |
| title_full | Major depressive disorder and the microbiome-gut-brain axis |
| title_fullStr | Major depressive disorder and the microbiome-gut-brain axis |
| title_full_unstemmed | Major depressive disorder and the microbiome-gut-brain axis |
| title_short | Major depressive disorder and the microbiome-gut-brain axis |
| title_sort | major depressive disorder and the microbiome gut brain axis |
| topic | dietary pattern major depressive disorder microbiota-gut-brain axis personalized treatment probiotics |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2025/05/Ouriaghli_97_2.pdf |
| work_keys_str_mv | AT fhouriaghli majordepressivedisorderandthemicrobiomegutbrainaxis AT iaelhaty majordepressivedisorderandthemicrobiomegutbrainaxis |