Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages
ABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis. Macrophages also greatly influence tumor progression by regulating the immune microenvironment. However, the role of polyamine met...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Smart Medicine |
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| Online Access: | https://doi.org/10.1002/smmd.70009 |
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| author | Haoran Ding Lingling Xue Shaoshi Zhu Ziyu Wang Huan Gui Guang Zhang Ning Tang Haozhen Ren Dayu Chen |
| author_facet | Haoran Ding Lingling Xue Shaoshi Zhu Ziyu Wang Huan Gui Guang Zhang Ning Tang Haozhen Ren Dayu Chen |
| author_sort | Haoran Ding |
| collection | DOAJ |
| description | ABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis. Macrophages also greatly influence tumor progression by regulating the immune microenvironment. However, the role of polyamine metabolism in thyroid cancer macrophages remains understudied. This study explores the connection between polyamine metabolism and macrophages in thyroid cancer. Using the THCA dataset gene expression analysis and single‐cell data, we identified macrophage subpopulations. We assessed immune scores, matrix scores, immune checkpoint scores, and immune cell types using Bulk‐RNA data and the TIDE platform to predict immune checkpoint inhibitor responses. Clinical specimens validated our findings. Our results show a significant association between polyamine metabolism and the clinical and biological characteristics of thyroid cancer, including macrophage trajectory. Notably, macrophage subpopulations affected by polyamine metabolism have strong prognostic value, especially in immunotherapy patients. We found that changes in these subpopulations correlate with thyroid cancer development, and tumor tissue can regulate macrophage polyamine metabolism. This study provides new insights into how polyamine metabolism affects macrophages and the tumor microenvironment, influencing tumor growth and anti‐tumor immune responses in thyroid cancer. |
| format | Article |
| id | doaj-art-c72df53da49243aa8bb244fc4f3c7a0a |
| institution | Kabale University |
| issn | 2751-1871 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-c72df53da49243aa8bb244fc4f3c7a0a2025-08-20T03:27:56ZengWiley-VCHSmart Medicine2751-18712025-06-0142n/an/a10.1002/smmd.70009Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated MacrophagesHaoran Ding0Lingling Xue1Shaoshi Zhu2Ziyu Wang3Huan Gui4Guang Zhang5Ning Tang6Haozhen Ren7Dayu Chen8Division of Thyroid Surgery Department of General Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Medical School Nanjing University Nanjing ChinaDivision of Hepatobiliary and Transplantation Surgery Department of General Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing ChinaCollege of Medicine University of Illinois Chicago Illinois USAJiamusi University Jiamusi ChinaJoint Research Unit Physiology of Nutritional Adaptation INRAE (National Research Institute for Agricultural, Food and Environmental) & University of Nantes Nantes FranceDivision of Hepatobiliary and Transplantation Surgery Department of General Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing ChinaDivision of Hepatobiliary and Transplantation Surgery Department of General Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing ChinaDivision of Hepatobiliary and Transplantation Surgery Department of General Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing ChinaDepartment of Pharmacy Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing ChinaABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis. Macrophages also greatly influence tumor progression by regulating the immune microenvironment. However, the role of polyamine metabolism in thyroid cancer macrophages remains understudied. This study explores the connection between polyamine metabolism and macrophages in thyroid cancer. Using the THCA dataset gene expression analysis and single‐cell data, we identified macrophage subpopulations. We assessed immune scores, matrix scores, immune checkpoint scores, and immune cell types using Bulk‐RNA data and the TIDE platform to predict immune checkpoint inhibitor responses. Clinical specimens validated our findings. Our results show a significant association between polyamine metabolism and the clinical and biological characteristics of thyroid cancer, including macrophage trajectory. Notably, macrophage subpopulations affected by polyamine metabolism have strong prognostic value, especially in immunotherapy patients. We found that changes in these subpopulations correlate with thyroid cancer development, and tumor tissue can regulate macrophage polyamine metabolism. This study provides new insights into how polyamine metabolism affects macrophages and the tumor microenvironment, influencing tumor growth and anti‐tumor immune responses in thyroid cancer.https://doi.org/10.1002/smmd.70009immunotherapymacrophagepolyamine metabolismthyroid carcinoma |
| spellingShingle | Haoran Ding Lingling Xue Shaoshi Zhu Ziyu Wang Huan Gui Guang Zhang Ning Tang Haozhen Ren Dayu Chen Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages Smart Medicine immunotherapy macrophage polyamine metabolism thyroid carcinoma |
| title | Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages |
| title_full | Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages |
| title_fullStr | Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages |
| title_full_unstemmed | Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages |
| title_short | Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages |
| title_sort | polyamine metabolism promotes the progression of thyroid carcinoma by regulating the immune phenotype of tumor associated macrophages |
| topic | immunotherapy macrophage polyamine metabolism thyroid carcinoma |
| url | https://doi.org/10.1002/smmd.70009 |
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