Role of NKT Cells in the Pathogenesis of NAFLD
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/850836 |
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| _version_ | 1832555434026729472 |
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| author | Kazuto Tajiri Yukihiro Shimizu |
| author_facet | Kazuto Tajiri Yukihiro Shimizu |
| author_sort | Kazuto Tajiri |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver. |
| format | Article |
| id | doaj-art-c72dcde787384a12b038db8815f26cf4 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-c72dcde787384a12b038db8815f26cf42025-02-03T05:48:15ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/850836850836Role of NKT Cells in the Pathogenesis of NAFLDKazuto Tajiri0Yukihiro Shimizu1The Third Department of Internal Medicine, Toyama University Hospital, Toyama, Toyama 930-0194, JapanGastroenterology Unit, Takaoka City Hospital, Takaoka, Toyama 933-8550, JapanNonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver.http://dx.doi.org/10.1155/2012/850836 |
| spellingShingle | Kazuto Tajiri Yukihiro Shimizu Role of NKT Cells in the Pathogenesis of NAFLD International Journal of Hepatology |
| title | Role of NKT Cells in the Pathogenesis of NAFLD |
| title_full | Role of NKT Cells in the Pathogenesis of NAFLD |
| title_fullStr | Role of NKT Cells in the Pathogenesis of NAFLD |
| title_full_unstemmed | Role of NKT Cells in the Pathogenesis of NAFLD |
| title_short | Role of NKT Cells in the Pathogenesis of NAFLD |
| title_sort | role of nkt cells in the pathogenesis of nafld |
| url | http://dx.doi.org/10.1155/2012/850836 |
| work_keys_str_mv | AT kazutotajiri roleofnktcellsinthepathogenesisofnafld AT yukihiroshimizu roleofnktcellsinthepathogenesisofnafld |