Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis.
<h4>Introduction</h4>The low incidence of oesophageal adenocarcinoma (EAC) in Barrett's oesophagus (BE) patients reinforces the need for risk stratification tools to make BE surveillance more effective. Therefore, we have undertaken a systematic review and meta-analysis of published...
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Public Library of Science (PLoS)
2017-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0186305 |
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| author | Vincent T Janmaat Sophie H van Olphen Katharina E Biermann Leendert H J Looijenga Marco B Bruno Manon C W Spaander |
| author_facet | Vincent T Janmaat Sophie H van Olphen Katharina E Biermann Leendert H J Looijenga Marco B Bruno Manon C W Spaander |
| author_sort | Vincent T Janmaat |
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| description | <h4>Introduction</h4>The low incidence of oesophageal adenocarcinoma (EAC) in Barrett's oesophagus (BE) patients reinforces the need for risk stratification tools to make BE surveillance more effective. Therefore, we have undertaken a systematic review and meta-analysis of published studies on immunohistochemical (IHC) biomarkers in BE to determine the value of IHC biomarkers as neoplastic predictors in BE surveillance.<h4>Materials and methods</h4>We searched MEDLINE, EMBASE, Web of Science, CENTRAL, Pubmed publisher, and Google scholar. All studies on IHC biomarkers in BE surveillance were included. ORs were extracted and meta-analyses performed with a random effects model.<h4>Results</h4>16 different IHC biomarkers were studied in 36 studies. These studies included 425 cases and 1835 controls. A meta- analysis was performed for p53, aspergillus oryzae lectin (AOL), Cyclin A, Cyclin D and alpha-methylacyl-CoA racemase. Aberrant p53 expression was significantly associated with an increased risk of neoplastic progression with an OR of 3.18 (95% CI 1.68 to 6.03). This association was confirmed for both non-dysplastic BE and BE with low-grade dysplasia (LGD). Another promising biomarker to predict neoplastic progression was AOL, with an OR of 3.04 (95% CI 2.05 to 4.49).<h4>Discussion</h4>Use of p53 IHC staining may improve risk stratification in BE surveillance. Aberrant p53 expression in BE patients appeared to be associated with a significantly increased risk of neoplastic progression for both non-dysplastic and LGD BE patients. |
| format | Article |
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| language | English |
| publishDate | 2017-01-01 |
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| spelling | doaj-art-c7240e1cb8cb4d4d916846299fcc5fdb2025-08-20T03:24:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018630510.1371/journal.pone.0186305Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis.Vincent T JanmaatSophie H van OlphenKatharina E BiermannLeendert H J LooijengaMarco B BrunoManon C W Spaander<h4>Introduction</h4>The low incidence of oesophageal adenocarcinoma (EAC) in Barrett's oesophagus (BE) patients reinforces the need for risk stratification tools to make BE surveillance more effective. Therefore, we have undertaken a systematic review and meta-analysis of published studies on immunohistochemical (IHC) biomarkers in BE to determine the value of IHC biomarkers as neoplastic predictors in BE surveillance.<h4>Materials and methods</h4>We searched MEDLINE, EMBASE, Web of Science, CENTRAL, Pubmed publisher, and Google scholar. All studies on IHC biomarkers in BE surveillance were included. ORs were extracted and meta-analyses performed with a random effects model.<h4>Results</h4>16 different IHC biomarkers were studied in 36 studies. These studies included 425 cases and 1835 controls. A meta- analysis was performed for p53, aspergillus oryzae lectin (AOL), Cyclin A, Cyclin D and alpha-methylacyl-CoA racemase. Aberrant p53 expression was significantly associated with an increased risk of neoplastic progression with an OR of 3.18 (95% CI 1.68 to 6.03). This association was confirmed for both non-dysplastic BE and BE with low-grade dysplasia (LGD). Another promising biomarker to predict neoplastic progression was AOL, with an OR of 3.04 (95% CI 2.05 to 4.49).<h4>Discussion</h4>Use of p53 IHC staining may improve risk stratification in BE surveillance. Aberrant p53 expression in BE patients appeared to be associated with a significantly increased risk of neoplastic progression for both non-dysplastic and LGD BE patients.https://doi.org/10.1371/journal.pone.0186305 |
| spellingShingle | Vincent T Janmaat Sophie H van Olphen Katharina E Biermann Leendert H J Looijenga Marco B Bruno Manon C W Spaander Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. PLoS ONE |
| title | Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. |
| title_full | Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. |
| title_fullStr | Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. |
| title_full_unstemmed | Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. |
| title_short | Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis. |
| title_sort | use of immunohistochemical biomarkers as independent predictor of neoplastic progression in barrett s oesophagus surveillance a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0186305 |
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