Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes

Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes

Abstract Background Beyond their conventional roles in hemostasis and wound healing, platelets have been shown to facilitate hematogenous metastasis by interacting with cancer cells. Depending on the activation route, platelets also generate different platelet-derived extracellular vesicles (PEVs) t...

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Bibliographic Details
Main Authors: Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Platelet
Extracellular vesicles
Melanoma
Functional assays
RNA sequencing
3D cell culture
Online Access:https://doi.org/10.1186/s12964-024-01973-4
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