Daphnetin may protect from SARS-CoV-2 infection by reducing ACE2

Daphnetin may protect from SARS-CoV-2 infection by reducing ACE2

Abstract To combat the SARS-CoV-2 pandemic, innovative prevention strategies are needed, including reducing ACE2 expression on respiratory cells. This study screened approved drugs in China for their ability to downregulate ACE2. Daphnetin (DAP) was found to significantly reduce ACE2 mRNA and protei...

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Bibliographic Details
Main Authors: Qian-wen Yang, Chang-ling Yue, Meng Chen, Yun-yun Ling, Qi Dong, Ying-xin Zhou, Yin Cao, Yan-xia Ding, Xu Zhao, Hai Huang, Zhao-huan Zhang, Lei Hu, Xiao-hui Xu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)
Angiotensin-converting enzyme 2 (ACE2)
Daphnetin (DAP)
Prevention
HIF-1α
JAK2
Online Access:https://doi.org/10.1038/s41598-024-79734-z
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