Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries
Abstract Background Diabetes mellitus (DM) is a global health issue associated with increased cardiovascular disease risk. Endothelial dysfunction is a known precursor to atherosclerosis and cardiovascular disease, and its role in the pathogenesis of DM complications is well-documented. There is lim...
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04314-y |
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| author | Asli Inci Atar Tugba Kayhan Altuner Huseyin Bozbas İlyas Atar Mehmet E. Korkmaz |
| author_facet | Asli Inci Atar Tugba Kayhan Altuner Huseyin Bozbas İlyas Atar Mehmet E. Korkmaz |
| author_sort | Asli Inci Atar |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus (DM) is a global health issue associated with increased cardiovascular disease risk. Endothelial dysfunction is a known precursor to atherosclerosis and cardiovascular disease, and its role in the pathogenesis of DM complications is well-documented. There is limited information in the evaluation of endothelial function in prediabetic patients using flow-mediated dilation (FMD), and studies have not excluded patients with known atherosclerosis or coronary artery disease. Thus, in this study, we aimed to evaluate the endothelial functions using FMD from the brachial artery of DM and prediabetes patients who had normal coronary arteries. Methods This study included 73 participants: 25 with DM, 25 with prediabetes, and 23 normoglycemic controls, all with normal coronary arteries on angiography. FMD measurements were conducted following established protocols, and statistical analysis was performed using standard methods to compare FMD levels among groups. Results The groups were comparable in clinical and demographic characteristics, except for fasting plasma glucose levels. Significant differences in FMD levels were observed: 10.1% in the DM group, 16.5% in the prediabetes group, and 14.8% in the control group (P = 0.004). Diabetic patients had significantly lower FMD levels than both prediabetic and normoglycemic individuals. No significant difference in FMD was found between prediabetic and control groups. Conclusions Diabetic patients exhibited significant endothelial dysfunction compared to normoglycemic individuals, while prediabetic patients did not show similar dysfunction. These findings suggest a window of opportunity in the prediabetic stage for early intervention to prevent advanced endothelial dysfunction. Trial registration number ISRCTN Registry ISRCTN15351014. Registry date: 23/09/2024. Retrospectively registered. |
| format | Article |
| id | doaj-art-c7185a9ffb954a6684d987d0553fc196 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-c7185a9ffb954a6684d987d0553fc1962025-08-20T02:50:05ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411610.1186/s12872-024-04314-yEndothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteriesAsli Inci Atar0Tugba Kayhan Altuner1Huseyin Bozbas2İlyas Atar3Mehmet E. Korkmaz4Ankara Bilkent City Hospital, BilkentAnkara Guven HospitalTOBB ETU HospitalAnkara Bilkent City Hospital, BilkentAnkara Bilkent City Hospital, BilkentAbstract Background Diabetes mellitus (DM) is a global health issue associated with increased cardiovascular disease risk. Endothelial dysfunction is a known precursor to atherosclerosis and cardiovascular disease, and its role in the pathogenesis of DM complications is well-documented. There is limited information in the evaluation of endothelial function in prediabetic patients using flow-mediated dilation (FMD), and studies have not excluded patients with known atherosclerosis or coronary artery disease. Thus, in this study, we aimed to evaluate the endothelial functions using FMD from the brachial artery of DM and prediabetes patients who had normal coronary arteries. Methods This study included 73 participants: 25 with DM, 25 with prediabetes, and 23 normoglycemic controls, all with normal coronary arteries on angiography. FMD measurements were conducted following established protocols, and statistical analysis was performed using standard methods to compare FMD levels among groups. Results The groups were comparable in clinical and demographic characteristics, except for fasting plasma glucose levels. Significant differences in FMD levels were observed: 10.1% in the DM group, 16.5% in the prediabetes group, and 14.8% in the control group (P = 0.004). Diabetic patients had significantly lower FMD levels than both prediabetic and normoglycemic individuals. No significant difference in FMD was found between prediabetic and control groups. Conclusions Diabetic patients exhibited significant endothelial dysfunction compared to normoglycemic individuals, while prediabetic patients did not show similar dysfunction. These findings suggest a window of opportunity in the prediabetic stage for early intervention to prevent advanced endothelial dysfunction. Trial registration number ISRCTN Registry ISRCTN15351014. Registry date: 23/09/2024. Retrospectively registered.https://doi.org/10.1186/s12872-024-04314-yFlow mediated dilationEndothelial dysfunctionAtherosclerosisDiabetes mellitusPrediabetesCoronary artery disease |
| spellingShingle | Asli Inci Atar Tugba Kayhan Altuner Huseyin Bozbas İlyas Atar Mehmet E. Korkmaz Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries BMC Cardiovascular Disorders Flow mediated dilation Endothelial dysfunction Atherosclerosis Diabetes mellitus Prediabetes Coronary artery disease |
| title | Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| title_full | Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| title_fullStr | Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| title_full_unstemmed | Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| title_short | Endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| title_sort | endothelial dysfunction in prediabetes and diabetes mellitus in patients with normal coronary arteries |
| topic | Flow mediated dilation Endothelial dysfunction Atherosclerosis Diabetes mellitus Prediabetes Coronary artery disease |
| url | https://doi.org/10.1186/s12872-024-04314-y |
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