Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors

Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors

Abstract Current cancer gene therapies rely primarily on antitumor immunity, but the exploration of alternative mRNA cargoes for direct antitumor effects is crucial to expand cancer gene therapies. Here we show that lipid nanoparticles (LNPs) carrying mRNA encoding a viral 3 C protease can efficient...

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Main Authors: Xiaotong Yang, Wei Li, Shaokang Yang, Zhuang Wang, Jiye Yin, Wenhao Zhang, Huimin Tao, Siqi Li, Xiaojia Guo, Qingsong Dai, Weiyan Zhu, Yuexiang Li, Xintong Yan, Chongda Luo, Jiazheng Li, Sichen Ren, Ping Wang, Yunfeng Shao, Yan Luo, Zhenyang Li, Jingjing Yang, Zhijie Chang, Ruiyuan Cao, Song Li, Wu Zhong
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59440-8
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