Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review
Mingyang Ren, Li Kang Department of Dermatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Li Kang, Email kangli100828@163.comAbstract: Xanthoma disseminatum (XD) is a rare normolipidemic mucocutaneous...
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Dove Medical Press
2025-06-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| author | Ren M Kang L |
| author_facet | Ren M Kang L |
| author_sort | Ren M |
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| description | Mingyang Ren, Li Kang Department of Dermatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Li Kang, Email kangli100828@163.comAbstract: Xanthoma disseminatum (XD) is a rare normolipidemic mucocutaneous xanthomatosis that falls within the spectrum of cutaneous non-Langerhans cell histiocytosis. The management of XD poses significant challenges due to the limited availability of clinical data. Here, we report a case of XD with disfiguring facial involvement that showed marked improvement following treatment with cladribine. The patient tolerated the treatment well, with no significant adverse effects observed except for a transient decrease in white blood cell count, which normalized after symptomatic treatment with appropriate oral medications. Additionally, we provide an updated review of the literature on the use of cladribine in XD. Through this case report and literature review, we aim to underscore both the potential benefits and limitations of cladribine therapy for patients with XD. Furthermore, we emphasize the critical importance of effective interdisciplinary collaboration between dermatology and oncology for the optimal management of this condition.Keywords: xanthoma disseminatum, disfiguring facial lesions, cladribine, adverse events |
| format | Article |
| id | doaj-art-c7134d3f7c1f4246a3f6e863b1e874f5 |
| institution | Kabale University |
| issn | 1178-7015 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj-art-c7134d3f7c1f4246a3f6e863b1e874f52025-08-20T03:28:25ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152025-06-01Volume 18Issue 116391644104360Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature ReviewRen M0Kang L1Department of DermatologyDepartment of DermatologyMingyang Ren, Li Kang Department of Dermatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Li Kang, Email kangli100828@163.comAbstract: Xanthoma disseminatum (XD) is a rare normolipidemic mucocutaneous xanthomatosis that falls within the spectrum of cutaneous non-Langerhans cell histiocytosis. The management of XD poses significant challenges due to the limited availability of clinical data. Here, we report a case of XD with disfiguring facial involvement that showed marked improvement following treatment with cladribine. The patient tolerated the treatment well, with no significant adverse effects observed except for a transient decrease in white blood cell count, which normalized after symptomatic treatment with appropriate oral medications. Additionally, we provide an updated review of the literature on the use of cladribine in XD. Through this case report and literature review, we aim to underscore both the potential benefits and limitations of cladribine therapy for patients with XD. Furthermore, we emphasize the critical importance of effective interdisciplinary collaboration between dermatology and oncology for the optimal management of this condition.Keywords: xanthoma disseminatum, disfiguring facial lesions, cladribine, adverse eventshttps://www.dovepress.com/challenges-in-the-treatment-of-xanthoma-disseminatum-improvement-in-di-peer-reviewed-fulltext-article-CCIDXanthoma disseminatumdisfiguring facial lesionscladribineadverse events |
| spellingShingle | Ren M Kang L Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review Clinical, Cosmetic and Investigational Dermatology Xanthoma disseminatum disfiguring facial lesions cladribine adverse events |
| title | Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review |
| title_full | Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review |
| title_fullStr | Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review |
| title_full_unstemmed | Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review |
| title_short | Challenges in the Treatment of Xanthoma Disseminatum: Improvement in Disfiguring Facial Lesions with Cladribine and Brief Updated Literature Review |
| title_sort | challenges in the treatment of xanthoma disseminatum improvement in disfiguring facial lesions with cladribine and brief updated literature review |
| topic | Xanthoma disseminatum disfiguring facial lesions cladribine adverse events |
| url | https://www.dovepress.com/challenges-in-the-treatment-of-xanthoma-disseminatum-improvement-in-di-peer-reviewed-fulltext-article-CCID |
| work_keys_str_mv | AT renm challengesinthetreatmentofxanthomadisseminatumimprovementindisfiguringfaciallesionswithcladribineandbriefupdatedliteraturereview AT kangl challengesinthetreatmentofxanthomadisseminatumimprovementindisfiguringfaciallesionswithcladribineandbriefupdatedliteraturereview |