Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report
Introduction: Osteonecrosis of the jaw is a serious condition often associated with the use of bone-modifying agents or antiangiogenics. Recent evidence suggests that immune checkpoint inhibitors, including Pembrolizumab, might also contribute to osteonecrosis of the jaw. Observation: An 83-year-old...
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| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | Journal of Oral Medicine and Oral Surgery |
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| Online Access: | https://www.jomos.org/articles/mbcb/full_html/2024/03/mbcb240188/mbcb240188.html |
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| author | Gosselin-Rousselle Louise Gaudimier Zoé Pamelard Pierre-Olivier Sader Paul Moizan Hervé |
| author_facet | Gosselin-Rousselle Louise Gaudimier Zoé Pamelard Pierre-Olivier Sader Paul Moizan Hervé |
| author_sort | Gosselin-Rousselle Louise |
| collection | DOAJ |
| description | Introduction: Osteonecrosis of the jaw is a serious condition often associated with the use of bone-modifying agents or antiangiogenics. Recent evidence suggests that immune checkpoint inhibitors, including Pembrolizumab, might also contribute to osteonecrosis of the jaw. Observation: An 83-year-old male with metastatic non-small cell lung cancer treated exclusively with Pembrolizumab developed osteonecrosis of the maxilla. Management included sequestrectomy, curettage, placement of Platelet-rich-Fibrin (PRF) and antibiotics. Despite initial improvement, symptoms recurred. The patient eventually stabilized but passed away a few months later. Discussion: A literature review was conducted supporting the hypothesis that the mechanism may involve disrupted bone remodeling due to enhanced immune activity. This highlights the need for further research to clarify the potential association between Pembrolizumab and osteonecrosis, and to develop preventive and management strategies. Conclusion: While definitive causality between Pembrolizumab and osteonecrosis of the jaw cannot be established with the current evidence, this case adds to the growing body of literature suggesting that immune checkpoint inhibitors may be implicated in the pathogenesis of osteonecrosis of the jaw. As the use of immunotherapy expands in oncology, further research is essential to elucidate this association and provide guidelines. |
| format | Article |
| id | doaj-art-c70d95a58d6646908c9947aed261946b |
| institution | Kabale University |
| issn | 2608-1326 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Journal of Oral Medicine and Oral Surgery |
| spelling | doaj-art-c70d95a58d6646908c9947aed261946b2025-02-07T08:24:38ZengEDP SciencesJournal of Oral Medicine and Oral Surgery2608-13262024-01-013033810.1051/mbcb/2024041mbcb240188Maxillary osteonecrosis linked to Pembrolizumab therapy: a case reportGosselin-Rousselle Louise0Gaudimier Zoé1Pamelard Pierre-Olivier2Sader Paul3Moizan Hervé4Service d'odontologie CHU de RouenService d'odontologie CHU de CréteilService d'odontologie CH du HavreService d'odontologie CHU de RouenService d'odontologie CHU de RouenIntroduction: Osteonecrosis of the jaw is a serious condition often associated with the use of bone-modifying agents or antiangiogenics. Recent evidence suggests that immune checkpoint inhibitors, including Pembrolizumab, might also contribute to osteonecrosis of the jaw. Observation: An 83-year-old male with metastatic non-small cell lung cancer treated exclusively with Pembrolizumab developed osteonecrosis of the maxilla. Management included sequestrectomy, curettage, placement of Platelet-rich-Fibrin (PRF) and antibiotics. Despite initial improvement, symptoms recurred. The patient eventually stabilized but passed away a few months later. Discussion: A literature review was conducted supporting the hypothesis that the mechanism may involve disrupted bone remodeling due to enhanced immune activity. This highlights the need for further research to clarify the potential association between Pembrolizumab and osteonecrosis, and to develop preventive and management strategies. Conclusion: While definitive causality between Pembrolizumab and osteonecrosis of the jaw cannot be established with the current evidence, this case adds to the growing body of literature suggesting that immune checkpoint inhibitors may be implicated in the pathogenesis of osteonecrosis of the jaw. As the use of immunotherapy expands in oncology, further research is essential to elucidate this association and provide guidelines.https://www.jomos.org/articles/mbcb/full_html/2024/03/mbcb240188/mbcb240188.htmlpembrolizumabosteonecrosismaxilla |
| spellingShingle | Gosselin-Rousselle Louise Gaudimier Zoé Pamelard Pierre-Olivier Sader Paul Moizan Hervé Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report Journal of Oral Medicine and Oral Surgery pembrolizumab osteonecrosis maxilla |
| title | Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report |
| title_full | Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report |
| title_fullStr | Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report |
| title_full_unstemmed | Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report |
| title_short | Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report |
| title_sort | maxillary osteonecrosis linked to pembrolizumab therapy a case report |
| topic | pembrolizumab osteonecrosis maxilla |
| url | https://www.jomos.org/articles/mbcb/full_html/2024/03/mbcb240188/mbcb240188.html |
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