DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER
Abstract. During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear. There is an increasing evidence to suggest an involvement of the complement sys...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/221 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849241432574918656 |
|---|---|
| author | G. M. Mkrtchyan L. P. Hovhannisyan A. A. Ayvazyan E. Y. Nazaretyan A. S. Boyajyan |
| author_facet | G. M. Mkrtchyan L. P. Hovhannisyan A. A. Ayvazyan E. Y. Nazaretyan A. S. Boyajyan |
| author_sort | G. M. Mkrtchyan |
| collection | DOAJ |
| description | Abstract. During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear. There is an increasing evidence to suggest an involvement of the complement system, the major inflammatory mediator, in FMF pathogeneses. In present study, we examined functional activities of the alternative and the classical complement cascades, and some relationships between alterations in the functional activities of these cascades in FMF. To this purpose, we measured hemolytic activities of classic (CH50) and alternative complement pathways (AH50), and of the complement components C3 (C3H50), factor B (fBH50) and factor D (fDH50) in blood serum of twenty-eight colchicine-free FMF patients and twenty-five healthy subjects. According to the data obtained, a decrease in serum levels of AH50 and increase in CH50 and C3H50 were detected in FMF patients, as compared to normal values. No significant difference was detected between the affected persons and healthy subjects for fBH50 and fDH50. Correlation analysis revealed a positive relationship between alterations in CH50 and C3H50 and a negative correlation between alterations in AH50 and CH50. From the data obtained, following conclusions have been made: 1) pathogenesis of FMF is characterized by a complement dysfunction, including hyperactivation of classical complement pathway and hypoactivation state of alternative pathway; 2) alterations in functional activities of classical and alternative complement activation pathways in FMF are interdependent; 3) the alternative pathway is suppressed on the initial stage of its activation; 4) high blood levels of C-reactive protein, serum amyloid P component, and circulating immune complexes, associated with FMF, might be responsible for hyperactivation of classical complement pathway in this disease. |
| format | Article |
| id | doaj-art-c707b270c16e44c184e53f834f5c00c1 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-c707b270c16e44c184e53f834f5c00c12025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111859010.15789/1563-0625-2009-1-85-90218DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVERG. M. Mkrtchyan0L. P. Hovhannisyan1A. A. Ayvazyan2E. Y. Nazaretyan3A. S. Boyajyan4Институт молекулярной биологии Национальной академии наук Республики Армения, г. ЕреванИнститут молекулярной биологии Национальной академии наук Республики Армения, г. ЕреванЕреванский государственный медицинский университетЕреванский государственный медицинский университетИнститут молекулярной биологии Национальной академии наук Республики Армения, г. ЕреванAbstract. During attacks of familial mediterranean fever (FMF), multiple systemic events are triggered, most of which promote autoinflammatory reactions. A molecular pattern of immune abnormalities in FMF is yet unclear. There is an increasing evidence to suggest an involvement of the complement system, the major inflammatory mediator, in FMF pathogeneses. In present study, we examined functional activities of the alternative and the classical complement cascades, and some relationships between alterations in the functional activities of these cascades in FMF. To this purpose, we measured hemolytic activities of classic (CH50) and alternative complement pathways (AH50), and of the complement components C3 (C3H50), factor B (fBH50) and factor D (fDH50) in blood serum of twenty-eight colchicine-free FMF patients and twenty-five healthy subjects. According to the data obtained, a decrease in serum levels of AH50 and increase in CH50 and C3H50 were detected in FMF patients, as compared to normal values. No significant difference was detected between the affected persons and healthy subjects for fBH50 and fDH50. Correlation analysis revealed a positive relationship between alterations in CH50 and C3H50 and a negative correlation between alterations in AH50 and CH50. From the data obtained, following conclusions have been made: 1) pathogenesis of FMF is characterized by a complement dysfunction, including hyperactivation of classical complement pathway and hypoactivation state of alternative pathway; 2) alterations in functional activities of classical and alternative complement activation pathways in FMF are interdependent; 3) the alternative pathway is suppressed on the initial stage of its activation; 4) high blood levels of C-reactive protein, serum amyloid P component, and circulating immune complexes, associated with FMF, might be responsible for hyperactivation of classical complement pathway in this disease.https://www.mimmun.ru/mimmun/article/view/221alternative complement pathwayclassic complement pathwayfamilial mediterranean fever |
| spellingShingle | G. M. Mkrtchyan L. P. Hovhannisyan A. A. Ayvazyan E. Y. Nazaretyan A. S. Boyajyan DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER Медицинская иммунология alternative complement pathway classic complement pathway familial mediterranean fever |
| title | DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER |
| title_full | DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER |
| title_fullStr | DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER |
| title_full_unstemmed | DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER |
| title_short | DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER |
| title_sort | dysfunction of complement system in familial mediterranean fever |
| topic | alternative complement pathway classic complement pathway familial mediterranean fever |
| url | https://www.mimmun.ru/mimmun/article/view/221 |
| work_keys_str_mv | AT gmmkrtchyan dysfunctionofcomplementsysteminfamilialmediterraneanfever AT lphovhannisyan dysfunctionofcomplementsysteminfamilialmediterraneanfever AT aaayvazyan dysfunctionofcomplementsysteminfamilialmediterraneanfever AT eynazaretyan dysfunctionofcomplementsysteminfamilialmediterraneanfever AT asboyajyan dysfunctionofcomplementsysteminfamilialmediterraneanfever |