Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects
Despite the great success in the diagnosis and treatment of immuno-inflammatory rheumatic diseases (IIRD), which led to a significant improvement in the prognosis in many patients, the fundamental medical problems of this pathology – the restoration of quality of life and reduction of mortality to t...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2019-03-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2668 |
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| _version_ | 1849400870703202304 |
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| author | E. L. Nasonov A. M. Lila |
| author_facet | E. L. Nasonov A. M. Lila |
| author_sort | E. L. Nasonov |
| collection | DOAJ |
| description | Despite the great success in the diagnosis and treatment of immuno-inflammatory rheumatic diseases (IIRD), which led to a significant improvement in the prognosis in many patients, the fundamental medical problems of this pathology – the restoration of quality of life and reduction of mortality to the population level – are far from solution. This served as a powerful impetus to the study of new approaches to pharmacotherapy of IIRD, one of which is associated with the use of low-molecular synthetic drugs that inhibit intracellular "signal" molecules-Janus kinase (JAK), the socalled Jakinibs. The current achievements and trends concerning the use of JAK inhibitors in the treatment of IIRD are considered. |
| format | Article |
| id | doaj-art-c703663e1b4348ebbcf66b5e508eecd6 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-c703663e1b4348ebbcf66b5e508eecd62025-08-20T03:37:53ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-03-0157181610.14412/1995-4484-2019-8-162443Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospectsE. L. Nasonov0A. M. Lila1Research Institute of Rheumatology; Department of Rheumatology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaResearch Institute of RheumatologyDespite the great success in the diagnosis and treatment of immuno-inflammatory rheumatic diseases (IIRD), which led to a significant improvement in the prognosis in many patients, the fundamental medical problems of this pathology – the restoration of quality of life and reduction of mortality to the population level – are far from solution. This served as a powerful impetus to the study of new approaches to pharmacotherapy of IIRD, one of which is associated with the use of low-molecular synthetic drugs that inhibit intracellular "signal" molecules-Janus kinase (JAK), the socalled Jakinibs. The current achievements and trends concerning the use of JAK inhibitors in the treatment of IIRD are considered.https://rsp.mediar-press.net/rsp/article/view/2668immuno-inflammatory rheumatic diseasescytokinesjak inhibitorstofacitinib |
| spellingShingle | E. L. Nasonov A. M. Lila Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects Научно-практическая ревматология immuno-inflammatory rheumatic diseases cytokines jak inhibitors tofacitinib |
| title | Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects |
| title_full | Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects |
| title_fullStr | Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects |
| title_full_unstemmed | Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects |
| title_short | Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects |
| title_sort | janus kinase inhibitors in immuno inflammatory rheumatic diseases new opportunities and prospects |
| topic | immuno-inflammatory rheumatic diseases cytokines jak inhibitors tofacitinib |
| url | https://rsp.mediar-press.net/rsp/article/view/2668 |
| work_keys_str_mv | AT elnasonov januskinaseinhibitorsinimmunoinflammatoryrheumaticdiseasesnewopportunitiesandprospects AT amlila januskinaseinhibitorsinimmunoinflammatoryrheumaticdiseasesnewopportunitiesandprospects |