Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis
Clinical and molecular-genetic examination and treatment of 140 patients with genital endometriosis is presented. Integrated treatment included surgery laparoscopic method and application of hormonal preparations (agonists gonadotropin releasing hormones, combined oral contraceptives). The most effe...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2012-12-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/857 |
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| author | V. N. Tkachyov A. S. Yurchenko I. D. Yevtushenko I. O. Naslednikova V. V. Novitsky O. I. Urazova K. S. Kublinsky P. A. Zakharova N. S. Menshikova |
| author_facet | V. N. Tkachyov A. S. Yurchenko I. D. Yevtushenko I. O. Naslednikova V. V. Novitsky O. I. Urazova K. S. Kublinsky P. A. Zakharova N. S. Menshikova |
| author_sort | V. N. Tkachyov |
| collection | DOAJ |
| description | Clinical and molecular-genetic examination and treatment of 140 patients with genital endometriosis is presented. Integrated treatment included surgery laparoscopic method and application of hormonal preparations (agonists gonadotropin releasing hormones, combined oral contraceptives). The most effective method of drug therapy of endometriosis after prior surgical correction was the appointment of agonists gonadotropin releasing hormone. The effectiveness of drug therapy of endometriosis correlated with special genes polymorphism of enzymes of biotransformation phase is "functionally defective genotypes 0/0" GSTT1 and GSTM1 0/0 are associated with low efficiency of medical treatment of the genital endometriosis. Assignment of drug therapy of endometriosis based on genetic polymorphism of an organism of the patient is appropriate. |
| format | Article |
| id | doaj-art-c6fce9db99aa4781a1bf1b7991a220fd |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-c6fce9db99aa4781a1bf1b7991a220fd2025-08-20T04:00:19ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842012-12-01116879010.20538/1682-0363-2012-6-87-90651Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosisV. N. Tkachyov0A. S. Yurchenko1I. D. Yevtushenko2I. O. Naslednikova3V. V. Novitsky4O. I. Urazova5K. S. Kublinsky6P. A. Zakharova7N. S. Menshikova8Сибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскClinical and molecular-genetic examination and treatment of 140 patients with genital endometriosis is presented. Integrated treatment included surgery laparoscopic method and application of hormonal preparations (agonists gonadotropin releasing hormones, combined oral contraceptives). The most effective method of drug therapy of endometriosis after prior surgical correction was the appointment of agonists gonadotropin releasing hormone. The effectiveness of drug therapy of endometriosis correlated with special genes polymorphism of enzymes of biotransformation phase is "functionally defective genotypes 0/0" GSTT1 and GSTM1 0/0 are associated with low efficiency of medical treatment of the genital endometriosis. Assignment of drug therapy of endometriosis based on genetic polymorphism of an organism of the patient is appropriate.https://bulletin.ssmu.ru/jour/article/view/857genital endometriosisglutathione-s-transferasethe effectiveness of treatment |
| spellingShingle | V. N. Tkachyov A. S. Yurchenko I. D. Yevtushenko I. O. Naslednikova V. V. Novitsky O. I. Urazova K. S. Kublinsky P. A. Zakharova N. S. Menshikova Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis Бюллетень сибирской медицины genital endometriosis glutathione-s-transferase the effectiveness of treatment |
| title | Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis |
| title_full | Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis |
| title_fullStr | Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis |
| title_full_unstemmed | Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis |
| title_short | Relationship of polymorphism of genes GSTT1 and GSTM1 on treatment efficacy of the genital endometriosis |
| title_sort | relationship of polymorphism of genes gstt1 and gstm1 on treatment efficacy of the genital endometriosis |
| topic | genital endometriosis glutathione-s-transferase the effectiveness of treatment |
| url | https://bulletin.ssmu.ru/jour/article/view/857 |
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