Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland
We present the first case in Switzerland of a patient with homozygous familial hypercholesterolaemia treated with evinacumab, a new recombinant human monoclonal antibody currently approved in Europe and in the USA but not yet in Switzerland. Homozygous familial hypercholesterolaemia is a rare genet...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2025-02-01
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| Series: | Swiss Medical Weekly |
| Online Access: | https://smw.ch/index.php/smw/article/view/4024 |
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| _version_ | 1850252586746118144 |
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| author | Noé Corpataux Fabienne Aregger Konstantinos C. Koskinas Catherine Gebhard |
| author_facet | Noé Corpataux Fabienne Aregger Konstantinos C. Koskinas Catherine Gebhard |
| author_sort | Noé Corpataux |
| collection | DOAJ |
| description |
We present the first case in Switzerland of a patient with homozygous familial hypercholesterolaemia treated with evinacumab, a new recombinant human monoclonal antibody currently approved in Europe and in the USA but not yet in Switzerland. Homozygous familial hypercholesterolaemia is a rare genetic disorder that causes severely elevated levels of low-density lipoprotein (LDL) cholesterol and early atherosclerotic cardiovascular disease, which, if left untreated, can lead to premature death. As a result of this newly introduced treatment, the patient’s LDL cholesterol levels were reduced by more than half, achieving recommended target values of secondary prevention for the first time. This case underscores the efficacy of evinacumab in achieving LDL cholesterol targets in homozygous familial hypercholesterolaemia patients and highlights the importance of early identification and treatment initiation.
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| format | Article |
| id | doaj-art-c6f4e99e0f4841579143faa52c00bde2 |
| institution | OA Journals |
| issn | 1424-3997 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj-art-c6f4e99e0f4841579143faa52c00bde22025-08-20T01:57:35ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972025-02-01155210.57187/s.4024Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in SwitzerlandNoé Corpataux0Fabienne AreggerKonstantinos C. KoskinasCatherine GebhardInselspital Bern We present the first case in Switzerland of a patient with homozygous familial hypercholesterolaemia treated with evinacumab, a new recombinant human monoclonal antibody currently approved in Europe and in the USA but not yet in Switzerland. Homozygous familial hypercholesterolaemia is a rare genetic disorder that causes severely elevated levels of low-density lipoprotein (LDL) cholesterol and early atherosclerotic cardiovascular disease, which, if left untreated, can lead to premature death. As a result of this newly introduced treatment, the patient’s LDL cholesterol levels were reduced by more than half, achieving recommended target values of secondary prevention for the first time. This case underscores the efficacy of evinacumab in achieving LDL cholesterol targets in homozygous familial hypercholesterolaemia patients and highlights the importance of early identification and treatment initiation. https://smw.ch/index.php/smw/article/view/4024 |
| spellingShingle | Noé Corpataux Fabienne Aregger Konstantinos C. Koskinas Catherine Gebhard Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland Swiss Medical Weekly |
| title | Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland |
| title_full | Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland |
| title_fullStr | Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland |
| title_full_unstemmed | Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland |
| title_short | Evinacumab for the treatment of homozygous familial hypercholesterolaemia: first patient case report in Switzerland |
| title_sort | evinacumab for the treatment of homozygous familial hypercholesterolaemia first patient case report in switzerland |
| url | https://smw.ch/index.php/smw/article/view/4024 |
| work_keys_str_mv | AT noecorpataux evinacumabforthetreatmentofhomozygousfamilialhypercholesterolaemiafirstpatientcasereportinswitzerland AT fabiennearegger evinacumabforthetreatmentofhomozygousfamilialhypercholesterolaemiafirstpatientcasereportinswitzerland AT konstantinosckoskinas evinacumabforthetreatmentofhomozygousfamilialhypercholesterolaemiafirstpatientcasereportinswitzerland AT catherinegebhard evinacumabforthetreatmentofhomozygousfamilialhypercholesterolaemiafirstpatientcasereportinswitzerland |