Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia
Aim. To evaluate the compliance and virological response to pegylated interferon alpha 2a treatment of chronic hepatitis B in Roma population compared to majority Caucasian population in Slovakia. Methods. Retrospective evaluation of a cohort of all Roma patients treated with pegylated interferon al...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/8682494 |
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| author | Sylvia Drazilova Martin Janicko Pavol Kristian Ivan Schreter Branislav Kucinsky Marek Kozlej Ivana Hockickova Peter Jarcuska |
| author_facet | Sylvia Drazilova Martin Janicko Pavol Kristian Ivan Schreter Branislav Kucinsky Marek Kozlej Ivana Hockickova Peter Jarcuska |
| author_sort | Sylvia Drazilova |
| collection | DOAJ |
| description | Aim. To evaluate the compliance and virological response to pegylated interferon alpha 2a treatment of chronic hepatitis B in Roma population compared to majority Caucasian population in Slovakia. Methods. Retrospective evaluation of a cohort of all Roma patients treated with pegylated interferon alpha 2a from 2007 to 2013 in 3 centers for treatment of chronic viral hepatitis B. The Study included 43 Roma patients with chronic viral hepatitis B and randomly selected control group. Treatment duration was 48 weeks. Viral response was evaluated after 24 weeks, at the end of treatment, and 24 weeks after the end of treatment. Results. Complete treatment course was finished by 79.1% of Roma patients compared to all patients from the control group p=0.0009. There was a tendency toward lower viral response rate in Roma at all time points; however significant difference was only at end of treatment viral response (51.2% Roma versus 81.4% majority, p=0.003). We also did not find significant difference at the rate of HBsAg loss. Conclusion. Roma patients with chronic hepatitis B have significantly worse compliance to treatment with pegylated interferon and they have significantly lower rate of end of treatment viral response. |
| format | Article |
| id | doaj-art-c6e963ccf72d49a09a8774fe75ff4e52 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c6e963ccf72d49a09a8774fe75ff4e522025-08-20T02:19:44ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/86824948682494Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern SlovakiaSylvia Drazilova0Martin Janicko1Pavol Kristian2Ivan Schreter3Branislav Kucinsky4Marek Kozlej5Ivana Hockickova6Peter Jarcuska7Department of Internal Medicine, Poprad Hospital, Banícka 28, 05845 Poprad, Slovakia1st Department of Internal Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, SlovakiaDepartment of Infectology and Travel Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, SlovakiaDepartment of Infectology and Travel Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, Slovakia1st Department of Internal Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, Slovakia1st Department of Internal Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, SlovakiaDepartment of Infectology and Travel Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, Slovakia1st Department of Internal Medicine, Medical Faculty of Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 04001 Košice, SlovakiaAim. To evaluate the compliance and virological response to pegylated interferon alpha 2a treatment of chronic hepatitis B in Roma population compared to majority Caucasian population in Slovakia. Methods. Retrospective evaluation of a cohort of all Roma patients treated with pegylated interferon alpha 2a from 2007 to 2013 in 3 centers for treatment of chronic viral hepatitis B. The Study included 43 Roma patients with chronic viral hepatitis B and randomly selected control group. Treatment duration was 48 weeks. Viral response was evaluated after 24 weeks, at the end of treatment, and 24 weeks after the end of treatment. Results. Complete treatment course was finished by 79.1% of Roma patients compared to all patients from the control group p=0.0009. There was a tendency toward lower viral response rate in Roma at all time points; however significant difference was only at end of treatment viral response (51.2% Roma versus 81.4% majority, p=0.003). We also did not find significant difference at the rate of HBsAg loss. Conclusion. Roma patients with chronic hepatitis B have significantly worse compliance to treatment with pegylated interferon and they have significantly lower rate of end of treatment viral response.http://dx.doi.org/10.1155/2016/8682494 |
| spellingShingle | Sylvia Drazilova Martin Janicko Pavol Kristian Ivan Schreter Branislav Kucinsky Marek Kozlej Ivana Hockickova Peter Jarcuska Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia Gastroenterology Research and Practice |
| title | Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia |
| title_full | Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia |
| title_fullStr | Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia |
| title_full_unstemmed | Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia |
| title_short | Lower Viral Response to Pegylated Interferon Alpha 2a Treatment of Chronic Hepatitis B in Roma People in Eastern Slovakia |
| title_sort | lower viral response to pegylated interferon alpha 2a treatment of chronic hepatitis b in roma people in eastern slovakia |
| url | http://dx.doi.org/10.1155/2016/8682494 |
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