Glutaminase inhibition ameliorates cancer-associated fibroblast lipid support of pancreatic cancer cell growth
Abstract Background Lipid homeostasis is critical for pancreatic adenocarcinoma (PDAC) cell survival under hypoxic and nutrient-deprived conditions. Hypoxia inhibits unsaturated lipid biosynthesis, compelling cancer cells to depend on exogenous unsaturated lipids to counteract saturated lipid-induce...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Cancer & Metabolism |
| Online Access: | https://doi.org/10.1186/s40170-025-00389-z |
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