Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status
Abstract Antimicrobial-resistant bacteria (ARBs) are serious global threat because they make it difficult to treat infections with antibiotics. Recently, it has been demonstrated that ARBs are isolated from the oral cavities of elderly individuals in long-term care facilities. Because oral ARBs can...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-90037-9 |
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| author | Saki Nishihama Miki Kawada-Matsuo Mi Nguyen-Tra Le Ayumi Fujii Azusa Haruta Toshiki Kajihara Yoshimasa Hashimoto Mineka Yoshikawa Tomonao Aikawa Kazuhiro Tsuga Hiroki Ohge Motoyuki Sugai Hideki Shiba Hitoshi Komatsuzawa |
| author_facet | Saki Nishihama Miki Kawada-Matsuo Mi Nguyen-Tra Le Ayumi Fujii Azusa Haruta Toshiki Kajihara Yoshimasa Hashimoto Mineka Yoshikawa Tomonao Aikawa Kazuhiro Tsuga Hiroki Ohge Motoyuki Sugai Hideki Shiba Hitoshi Komatsuzawa |
| author_sort | Saki Nishihama |
| collection | DOAJ |
| description | Abstract Antimicrobial-resistant bacteria (ARBs) are serious global threat because they make it difficult to treat infections with antibiotics. Recently, it has been demonstrated that ARBs are isolated from the oral cavities of elderly individuals in long-term care facilities. Because oral ARBs can cause systemic diseases such as bacteraemia and aspiration pneumonia, more attention must be given to protect the overall health of elderly people. To understand the prevalence of oral ARBs, more studies are needed in addition to previous studies. In this study, we investigated oral ARBs in elderly people receiving home health care (HHC) who had different lifestyles as residents in long-term care facilities. Among 98 HHC participants, Staphylococcus aureus, including 8 methicillin-resistant S. aureus (MRSA) strains, was isolated from 31 participants (31.7%), and 3rd-generation cephalosporin-resistant gram-negative bacteria (GNARB) were isolated from 18 participants (17.8%). An analysis of the relationship between oral ARBs and clinical status revealed that S. aureus/MRSA isolation was correlated with denture condition, while GNARB isolation was correlated with tube feeding. This study is the first comprehensive analysis of ARB carriage in the oral cavities of elderly people in HHCs. These results demonstrate the potential risk of oral ARB carriage and the importance of infection control in HHCs. |
| format | Article |
| id | doaj-art-c6dc531ad4954f3b9ee17a6b9a13db15 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c6dc531ad4954f3b9ee17a6b9a13db152025-08-20T02:15:16ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-90037-9Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic statusSaki Nishihama0Miki Kawada-Matsuo1Mi Nguyen-Tra Le2Ayumi Fujii3Azusa Haruta4Toshiki Kajihara5Yoshimasa Hashimoto6Mineka Yoshikawa7Tomonao Aikawa8Kazuhiro Tsuga9Hiroki Ohge10Motoyuki Sugai11Hideki Shiba12Hitoshi Komatsuzawa13Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University Project Research Center for Infectious Diseases, Hiroshima UniversityHashimoto-naikaDepartment of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University Project Research Center for Infectious Diseases, Hiroshima UniversityProject Research Center for Infectious Diseases, Hiroshima UniversityDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityAbstract Antimicrobial-resistant bacteria (ARBs) are serious global threat because they make it difficult to treat infections with antibiotics. Recently, it has been demonstrated that ARBs are isolated from the oral cavities of elderly individuals in long-term care facilities. Because oral ARBs can cause systemic diseases such as bacteraemia and aspiration pneumonia, more attention must be given to protect the overall health of elderly people. To understand the prevalence of oral ARBs, more studies are needed in addition to previous studies. In this study, we investigated oral ARBs in elderly people receiving home health care (HHC) who had different lifestyles as residents in long-term care facilities. Among 98 HHC participants, Staphylococcus aureus, including 8 methicillin-resistant S. aureus (MRSA) strains, was isolated from 31 participants (31.7%), and 3rd-generation cephalosporin-resistant gram-negative bacteria (GNARB) were isolated from 18 participants (17.8%). An analysis of the relationship between oral ARBs and clinical status revealed that S. aureus/MRSA isolation was correlated with denture condition, while GNARB isolation was correlated with tube feeding. This study is the first comprehensive analysis of ARB carriage in the oral cavities of elderly people in HHCs. These results demonstrate the potential risk of oral ARB carriage and the importance of infection control in HHCs.https://doi.org/10.1038/s41598-025-90037-9Antimicrobial-resistant bacteriaElderlyHome healthcareOral cavity. |
| spellingShingle | Saki Nishihama Miki Kawada-Matsuo Mi Nguyen-Tra Le Ayumi Fujii Azusa Haruta Toshiki Kajihara Yoshimasa Hashimoto Mineka Yoshikawa Tomonao Aikawa Kazuhiro Tsuga Hiroki Ohge Motoyuki Sugai Hideki Shiba Hitoshi Komatsuzawa Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status Scientific Reports Antimicrobial-resistant bacteria Elderly Home healthcare Oral cavity. |
| title | Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status |
| title_full | Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status |
| title_fullStr | Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status |
| title_full_unstemmed | Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status |
| title_short | Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status |
| title_sort | oral colonization of antimicrobial resistant bacteria in home health care participants and their association with oral and systemic status |
| topic | Antimicrobial-resistant bacteria Elderly Home healthcare Oral cavity. |
| url | https://doi.org/10.1038/s41598-025-90037-9 |
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