The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum)
Abstract Earthworms have been extensively studied as ancient soil invertebrates, that are highly diverse. Previous studies of these invertebrates have mainly focused on their ecosystem services, medicinal value, and ecological habits. However, their genomic analysis remains inadequate. In this study...
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Nature Portfolio
2025-06-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-05058-w |
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| author | Guangquan Peng Yanghe Qin Zhiming Yan Mingwei He Yucheng Zhao Neng Jiang Changhong Wei |
| author_facet | Guangquan Peng Yanghe Qin Zhiming Yan Mingwei He Yucheng Zhao Neng Jiang Changhong Wei |
| author_sort | Guangquan Peng |
| collection | DOAJ |
| description | Abstract Earthworms have been extensively studied as ancient soil invertebrates, that are highly diverse. Previous studies of these invertebrates have mainly focused on their ecosystem services, medicinal value, and ecological habits. However, their genomic analysis remains inadequate. In this study, we generated the first high-quality telomere-to-telomere (T2T) assembly of the genome of the earthworm, Amynthas aspergillum (Perrier, 1872), which belongs to the genus Amynthas of the family Megascolecidae. The T2T assembly was 758.86 Mb with an N50 contig size of 16.59 Mb. The sequences were anchored to 43 chromosomes (2n = 2x = 86) with a coverage of 98.43% (746.95 Mb), and 83 telomeres were detected. In addition, we also predicted 35,723 protein-coding genes with 97.02% being functionally annotated. This T2T genome assembly will establish substantial groundwork for exploring the evolutionary mechanisms of the earthworm genome and enhance the specificity of its pharmacological effects. |
| format | Article |
| id | doaj-art-c6d7afd1adcd40cfb88fae0fb397289f |
| institution | OA Journals |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-c6d7afd1adcd40cfb88fae0fb397289f2025-08-20T02:30:43ZengNature PortfolioScientific Data2052-44632025-06-011211910.1038/s41597-025-05058-wThe high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum)Guangquan Peng0Yanghe Qin1Zhiming Yan2Mingwei He3Yucheng Zhao4Neng Jiang5Changhong Wei6Department of Research & Clinical Laboratory, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of NanningDepartment of Pharmacy, Guangxi Medical University Cancer HospitalDepartment of Pharmacy, Guangxi Medical University Cancer HospitalDepartment of Pharmacy, Guangxi Medical University Cancer HospitalState Key Laboratory of Natural Medicines, Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical UniversityDepartment of Pharmacy, Guangxi Medical University Cancer HospitalDepartment of Research & Clinical Laboratory, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of NanningAbstract Earthworms have been extensively studied as ancient soil invertebrates, that are highly diverse. Previous studies of these invertebrates have mainly focused on their ecosystem services, medicinal value, and ecological habits. However, their genomic analysis remains inadequate. In this study, we generated the first high-quality telomere-to-telomere (T2T) assembly of the genome of the earthworm, Amynthas aspergillum (Perrier, 1872), which belongs to the genus Amynthas of the family Megascolecidae. The T2T assembly was 758.86 Mb with an N50 contig size of 16.59 Mb. The sequences were anchored to 43 chromosomes (2n = 2x = 86) with a coverage of 98.43% (746.95 Mb), and 83 telomeres were detected. In addition, we also predicted 35,723 protein-coding genes with 97.02% being functionally annotated. This T2T genome assembly will establish substantial groundwork for exploring the evolutionary mechanisms of the earthworm genome and enhance the specificity of its pharmacological effects.https://doi.org/10.1038/s41597-025-05058-w |
| spellingShingle | Guangquan Peng Yanghe Qin Zhiming Yan Mingwei He Yucheng Zhao Neng Jiang Changhong Wei The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) Scientific Data |
| title | The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) |
| title_full | The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) |
| title_fullStr | The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) |
| title_full_unstemmed | The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) |
| title_short | The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) |
| title_sort | high quality telomere to telomere genome assembly of the earthworm amynthas aspergillum |
| url | https://doi.org/10.1038/s41597-025-05058-w |
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