Metallothionein-3-mediated intracellular zinc mediates antioxidant and anti-inflammatory responses in the complete Freund’s adjuvant-induced inflammatory pain mouse model
Abstract Chronic inflammatory pain is often caused by peripheral tissue damage and persistent inflammation. This disease substantially affects patients’ physical and social well-being. We investigated the role of metallothionein-3 (MT3) in modulating complete Freund’s adjuvant (CFA)-induced intracel...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-02-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02322-1 |
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| Summary: | Abstract Chronic inflammatory pain is often caused by peripheral tissue damage and persistent inflammation. This disease substantially affects patients’ physical and social well-being. We investigated the role of metallothionein-3 (MT3) in modulating complete Freund’s adjuvant (CFA)-induced intracellular Zn2+ activity in an MT3 knockout mouse model of inflammatory pain in the hind paw. The results demonstrated that increasing intracellular Zn2+ levels ameliorate deficits in motor behavior, as well as inflammation in the paw, spleen, and thymus. Furthermore, intracellular Zn2+ was crucial in regulating oxidative stress markers (glutathione, superoxide dismutase, catalase, and malondialdehyde) and inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, in MT3 knockout mice induced with CFA. This study highlights the critical role of MT3 in coordinating the intracellular interaction with Zn2+, which is vital for the immune systems’s protective functions. These interactions are fundamental for maintaining metal ion homeostasis and regulating the synthesis of various biomolecules in the body. |
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| ISSN: | 2058-7716 |