Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy

Robert Seby,1 Benjamin J McCormick,1 Emily Wolf,2 Justin Kuhlman,2 Nikita Jhawar,1 Sven Peter Oman,1 Adam M Kase,2 Chancey Christenson,3 Marwan Shaikh2 1Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA; 3Depar...

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Main Authors: Seby R, McCormick BJ, Wolf E, Kuhlman J, Jhawar N, Oman SP, Kase AM, Christenson C, Shaikh M
Format: Article
Language:English
Published: Dove Medical Press 2025-07-01
Series:Journal of Blood Medicine
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Online Access:https://www.dovepress.com/respiratory-syncytial-virus-vaccine-induced-thrombotic-microangiopathy-peer-reviewed-fulltext-article-JBM
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author Seby R
McCormick BJ
Wolf E
Kuhlman J
Jhawar N
Oman SP
Kase AM
Christenson C
Shaikh M
author_facet Seby R
McCormick BJ
Wolf E
Kuhlman J
Jhawar N
Oman SP
Kase AM
Christenson C
Shaikh M
author_sort Seby R
collection DOAJ
description Robert Seby,1 Benjamin J McCormick,1 Emily Wolf,2 Justin Kuhlman,2 Nikita Jhawar,1 Sven Peter Oman,1 Adam M Kase,2 Chancey Christenson,3 Marwan Shaikh2 1Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA; 3Department of Pathology and Transfusion Medicine, Mayo Clinic, Jacksonville, FL, USACorrespondence: Robert Seby, Email seby.robert@mayo.eduAbstract: Microangiopathic hemolytic anemia with associated multiorgan failure is a medical emergency. The differential diagnosis for microangiopathic hemolytic anemia is broad and requires a systematic, focused approach at ruling out serious causes. However, with the rise of new vaccines and sporadic reports of vaccine-induced microangiopathic hemolytic anemia, it is essential for providers to include vaccines as a potential cause on their differential diagnosis. Here, we report the first case of respiratory syncytial virus vaccine-induced microangiopathic hemolytic anemia, anuric renal failure, and metabolic encephalopathy in the world.Keywords: microangiopathic hemolytic anemia, respiratory syncytial virus, renal failure, metabolic encephalopathy
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publishDate 2025-07-01
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series Journal of Blood Medicine
spelling doaj-art-c6d4f1932006482bbfa01ad414cf691b2025-08-20T03:08:21ZengDove Medical PressJournal of Blood Medicine1179-27362025-07-01Volume 16Issue 1331335105038Respiratory Syncytial Virus Vaccine Induced Thrombotic MicroangiopathySeby R0McCormick BJWolf E1Kuhlman J2Jhawar N3Oman SP4Kase AM5Christenson C6Shaikh M7internal medicineHematology and OncologyDepartment of Internal MedicineInternal MedicineHospital Internal MedicineHematology OncologyDepartment of Laboratory Medicine and PathologyHematology/OncologyRobert Seby,1 Benjamin J McCormick,1 Emily Wolf,2 Justin Kuhlman,2 Nikita Jhawar,1 Sven Peter Oman,1 Adam M Kase,2 Chancey Christenson,3 Marwan Shaikh2 1Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA; 3Department of Pathology and Transfusion Medicine, Mayo Clinic, Jacksonville, FL, USACorrespondence: Robert Seby, Email seby.robert@mayo.eduAbstract: Microangiopathic hemolytic anemia with associated multiorgan failure is a medical emergency. The differential diagnosis for microangiopathic hemolytic anemia is broad and requires a systematic, focused approach at ruling out serious causes. However, with the rise of new vaccines and sporadic reports of vaccine-induced microangiopathic hemolytic anemia, it is essential for providers to include vaccines as a potential cause on their differential diagnosis. Here, we report the first case of respiratory syncytial virus vaccine-induced microangiopathic hemolytic anemia, anuric renal failure, and metabolic encephalopathy in the world.Keywords: microangiopathic hemolytic anemia, respiratory syncytial virus, renal failure, metabolic encephalopathyhttps://www.dovepress.com/respiratory-syncytial-virus-vaccine-induced-thrombotic-microangiopathy-peer-reviewed-fulltext-article-JBMmicroangiopathic hemolytic anemiarespiratory syncytial virusrenal failuremetabolic encephalopathy.
spellingShingle Seby R
McCormick BJ
Wolf E
Kuhlman J
Jhawar N
Oman SP
Kase AM
Christenson C
Shaikh M
Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
Journal of Blood Medicine
microangiopathic hemolytic anemia
respiratory syncytial virus
renal failure
metabolic encephalopathy.
title Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
title_full Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
title_fullStr Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
title_full_unstemmed Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
title_short Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy
title_sort respiratory syncytial virus vaccine induced thrombotic microangiopathy
topic microangiopathic hemolytic anemia
respiratory syncytial virus
renal failure
metabolic encephalopathy.
url https://www.dovepress.com/respiratory-syncytial-virus-vaccine-induced-thrombotic-microangiopathy-peer-reviewed-fulltext-article-JBM
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