Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging
Abstract A simple, one-pot and green method is reported for hydrothermal synthesis of highly fluorescent and magnetic carbon dots (CDs) by using D-glucose, as the carbon source. CDs were fully characterized by the UV-Vis and fluorescence spectroscopy, DLS, FTIR, TEM, EDS, XRD, and VSM. The nitrogen...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80531-x |
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| author | Abolghasem Abbasi Kajani Ali Pouresmaeili Masoud Ayatollahi Mehrgardi Shaghayegh Haghjooy Javanmard |
| author_facet | Abolghasem Abbasi Kajani Ali Pouresmaeili Masoud Ayatollahi Mehrgardi Shaghayegh Haghjooy Javanmard |
| author_sort | Abolghasem Abbasi Kajani |
| collection | DOAJ |
| description | Abstract A simple, one-pot and green method is reported for hydrothermal synthesis of highly fluorescent and magnetic carbon dots (CDs) by using D-glucose, as the carbon source. CDs were fully characterized by the UV-Vis and fluorescence spectroscopy, DLS, FTIR, TEM, EDS, XRD, and VSM. The nitrogen doping of different diamines significantly improved the fluorescence quantum yield (QY) of CDs with the maximum effect obtained by using m-phenylenediamine (mPDA). Temperature and reaction time also affected the QY of CDs with the best results obtained at 150 °C for 3 h. The heteroatom doping by innovative use of different metal sulfates including FeSO4, MnSO4, CuSO4, MgSO4, and ZnSO4, further improved the optical properties of CDs. Interestingly, the magnetic and multicolor CDs with high colloidal stability and QYs of 17.7, 16.5, and 53.9% at 460, 490, and 515 nm, respectively, were synthesized by using 0.1 M of glucose, mPDA and MnSO4. The resulted Mn-, S-, N-doped CDs represented rapid uptake and high-quality fluorescence imaging of the human fibroblast and umbilical vein endothelial cells in vitro, without significant toxicity. The CDs also displayed high r 1 relaxivity of 32.3 mM− 1 s− 1 and were used for high-contrast MR and fluorescence imaging of mouse tumor models, in vivo. |
| format | Article |
| id | doaj-art-c6d4191408fb4ebb87dd5278b48af01a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-c6d4191408fb4ebb87dd5278b48af01a2025-08-20T02:08:20ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-80531-xHeteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imagingAbolghasem Abbasi Kajani0Ali Pouresmaeili1Masoud Ayatollahi Mehrgardi2Shaghayegh Haghjooy Javanmard3Department of Biotechnology, Faculty of Biological Science and Technology, University of IsfahanDepartment of Biotechnology, Faculty of Biological Science and Technology, University of IsfahanDepartment of Chemistry, University of IsfahanPersonalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesAbstract A simple, one-pot and green method is reported for hydrothermal synthesis of highly fluorescent and magnetic carbon dots (CDs) by using D-glucose, as the carbon source. CDs were fully characterized by the UV-Vis and fluorescence spectroscopy, DLS, FTIR, TEM, EDS, XRD, and VSM. The nitrogen doping of different diamines significantly improved the fluorescence quantum yield (QY) of CDs with the maximum effect obtained by using m-phenylenediamine (mPDA). Temperature and reaction time also affected the QY of CDs with the best results obtained at 150 °C for 3 h. The heteroatom doping by innovative use of different metal sulfates including FeSO4, MnSO4, CuSO4, MgSO4, and ZnSO4, further improved the optical properties of CDs. Interestingly, the magnetic and multicolor CDs with high colloidal stability and QYs of 17.7, 16.5, and 53.9% at 460, 490, and 515 nm, respectively, were synthesized by using 0.1 M of glucose, mPDA and MnSO4. The resulted Mn-, S-, N-doped CDs represented rapid uptake and high-quality fluorescence imaging of the human fibroblast and umbilical vein endothelial cells in vitro, without significant toxicity. The CDs also displayed high r 1 relaxivity of 32.3 mM− 1 s− 1 and were used for high-contrast MR and fluorescence imaging of mouse tumor models, in vivo.https://doi.org/10.1038/s41598-024-80531-xCarbon dotsGlucoseHeteroatom dopingFluorescence imagingMRI |
| spellingShingle | Abolghasem Abbasi Kajani Ali Pouresmaeili Masoud Ayatollahi Mehrgardi Shaghayegh Haghjooy Javanmard Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging Scientific Reports Carbon dots Glucose Heteroatom doping Fluorescence imaging MRI |
| title | Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging |
| title_full | Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging |
| title_fullStr | Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging |
| title_full_unstemmed | Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging |
| title_short | Heteroatom-doped magneto-fluorescent carbon dots, a potent agent for multimodal imaging |
| title_sort | heteroatom doped magneto fluorescent carbon dots a potent agent for multimodal imaging |
| topic | Carbon dots Glucose Heteroatom doping Fluorescence imaging MRI |
| url | https://doi.org/10.1038/s41598-024-80531-x |
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