The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study
ABSTRACT Background Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise‐induced hearing loss (NIHL) patients during long‐term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system. Objective T...
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Wiley
2025-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70465 |
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| author | Wei Lian Lei Zhang Aijie Wang Ranran Huang Haijun Zhang Xianghua Bao GuoweiZ hang |
| author_facet | Wei Lian Lei Zhang Aijie Wang Ranran Huang Haijun Zhang Xianghua Bao GuoweiZ hang |
| author_sort | Wei Lian |
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| description | ABSTRACT Background Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise‐induced hearing loss (NIHL) patients during long‐term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system. Objective To investigate the functional connectivity (FC) of the default mode network (DMN) and visual network (VN) in patients with occupational NIHL using resting‐state functional magnetic resonance imaging (rs‐fMRI). Methods Ninety‐eight people with NIHL and 78 healthy controls (HCs) matched for age and educational level were enrolled. The mini–mental state examination (MMSE) was conducted, and rs‐fMRI scanning was performed. The data were processed and analyzed to identify FC changes between DMN, VN, and the whole brain. Results Compared with the HCs, the NIHL group showed significantly enhanced connectivity with multiple brain regions when utilizing the DMN as seed regions of interest (ROI), with only some brain regions showing significantly decreased connectivity. When the VN was used as the seed ROI, the NIHL group showed significantly enhanced connectivity with multiple brain regions (corrected by GRF, p < 0.05). In the present study, the FC between multiple brain areas of VN and DMN in the NIHL patient group was enhanced compared to the normal population. The phenomenon of “perceptual compensation” is confirmed. The results of this study suggest that NIHL causes various changes in brain function related to emotion, decision‐making, social cognition, and psychopathology. It suggests that changes in brain functional networks involve complex processes involving plasticity and damage to multiple networks. Conclusions The NIHL patients showed abnormal FC changes in both the DMN and VN, indicating widespread multimodal plasticity and reorganization of nonauditory central nervous system functions in people with NIHL. |
| format | Article |
| id | doaj-art-c6d1d854ecbe4fd080fa597a451fa324 |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-c6d1d854ecbe4fd080fa597a451fa3242025-08-20T02:20:03ZengWileyBrain and Behavior2162-32792025-04-01154n/an/a10.1002/brb3.70465The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI StudyWei Lian0Lei Zhang1Aijie Wang2Ranran Huang3Haijun Zhang4Xianghua Bao5GuoweiZ hang6Department of Radiology Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Radiology Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Radiology Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Radiology Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Radiology Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Occupational Yantaishan Hospital Yantai People's Republic of ChinaDepartment of Radiology Yantaishan Hospital Yantai People's Republic of ChinaABSTRACT Background Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise‐induced hearing loss (NIHL) patients during long‐term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system. Objective To investigate the functional connectivity (FC) of the default mode network (DMN) and visual network (VN) in patients with occupational NIHL using resting‐state functional magnetic resonance imaging (rs‐fMRI). Methods Ninety‐eight people with NIHL and 78 healthy controls (HCs) matched for age and educational level were enrolled. The mini–mental state examination (MMSE) was conducted, and rs‐fMRI scanning was performed. The data were processed and analyzed to identify FC changes between DMN, VN, and the whole brain. Results Compared with the HCs, the NIHL group showed significantly enhanced connectivity with multiple brain regions when utilizing the DMN as seed regions of interest (ROI), with only some brain regions showing significantly decreased connectivity. When the VN was used as the seed ROI, the NIHL group showed significantly enhanced connectivity with multiple brain regions (corrected by GRF, p < 0.05). In the present study, the FC between multiple brain areas of VN and DMN in the NIHL patient group was enhanced compared to the normal population. The phenomenon of “perceptual compensation” is confirmed. The results of this study suggest that NIHL causes various changes in brain function related to emotion, decision‐making, social cognition, and psychopathology. It suggests that changes in brain functional networks involve complex processes involving plasticity and damage to multiple networks. Conclusions The NIHL patients showed abnormal FC changes in both the DMN and VN, indicating widespread multimodal plasticity and reorganization of nonauditory central nervous system functions in people with NIHL.https://doi.org/10.1002/brb3.70465default mode network (DMN)functional connectivity (FC)functional magnetic resonance imaging (fMRI)noise‐induced hearing loss (NIHL)visual network (VN) |
| spellingShingle | Wei Lian Lei Zhang Aijie Wang Ranran Huang Haijun Zhang Xianghua Bao GuoweiZ hang The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study Brain and Behavior default mode network (DMN) functional connectivity (FC) functional magnetic resonance imaging (fMRI) noise‐induced hearing loss (NIHL) visual network (VN) |
| title | The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study |
| title_full | The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study |
| title_fullStr | The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study |
| title_full_unstemmed | The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study |
| title_short | The Default Mode Network and Visual Network Functional Connectivity Changes in Noise‐Induced Hearing Loss Patients: A Resting‐State fMRI Study |
| title_sort | default mode network and visual network functional connectivity changes in noise induced hearing loss patients a resting state fmri study |
| topic | default mode network (DMN) functional connectivity (FC) functional magnetic resonance imaging (fMRI) noise‐induced hearing loss (NIHL) visual network (VN) |
| url | https://doi.org/10.1002/brb3.70465 |
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