Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine

Abstract We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic development, within the prospective permanent articular cart...

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Main Authors: Sara Caxaria, Nikolaos Kouvatsos, Suzanne E Eldridge, Mario Alvarez‐Fallas, Anne‐Sophie Thorup, Daniela Cici, Aida Barawi, Ammaarah Arshed, Danielle Strachan, Giulia Carletti, Xinying Huang, Sabah Bharde, Melody Deniz, Jacob Wilson, Bethan L Thomas, Costantino Pitzalis, Francesco Paolo Cantatore, Manasi Sayilekshmy, Shafaq Sikandar, Frank P Luyten, Thomas Pap, Joanna C Sherwood, Anthony J Day, Francesco Dell'Accio
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
chemokine
chondrogenesis
CXCL6
GCP‐2
osteoarthritis
Online Access:https://doi.org/10.15252/emmm.202216218
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