Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis
Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of...
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University of Baghdad, College of Science for Women
2024-08-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8808 |
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| author | Noor Basil Ghanim Bushra Faris Hasan |
| author_facet | Noor Basil Ghanim Bushra Faris Hasan |
| author_sort | Noor Basil Ghanim |
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Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of amino acids produced from the degradation of type II collagen, which is abundantly found in the cartilage, followed by a nitration in the tyrosine residue as a consequence of stress-inflammatory events. In this study, Coll2-1NO2 is used as a biomarker of OA to predict the inflammatory stress condition as well as the cartilage degradation in pre- and post-menopausal women. The results showed a significant increase of serum Coll2-1NO2 in pre- and post-menopausal women with OA compared to pre- and post-menopausal health women, at similar body mass index category (overweight). Pearson’s correlation analysis showed non-significant association between Coll2-1NO2 and other studied parameters. Moreover, ROC analysis showed a very excellent sensitivity of Coll2-1NO2 as a prognostic biomarker for OA disease in pre- and post-menopausal women
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| format | Article |
| id | doaj-art-c6cbacb9c63a49ab8f63777f07de5ba3 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-c6cbacb9c63a49ab8f63777f07de5ba32025-08-20T03:20:15ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-08-0121810.21123/bsj.2024.8808Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with OsteoarthritisNoor Basil Ghanim0https://orcid.org/0009-0009-4158-6128Bushra Faris Hasan1Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of amino acids produced from the degradation of type II collagen, which is abundantly found in the cartilage, followed by a nitration in the tyrosine residue as a consequence of stress-inflammatory events. In this study, Coll2-1NO2 is used as a biomarker of OA to predict the inflammatory stress condition as well as the cartilage degradation in pre- and post-menopausal women. The results showed a significant increase of serum Coll2-1NO2 in pre- and post-menopausal women with OA compared to pre- and post-menopausal health women, at similar body mass index category (overweight). Pearson’s correlation analysis showed non-significant association between Coll2-1NO2 and other studied parameters. Moreover, ROC analysis showed a very excellent sensitivity of Coll2-1NO2 as a prognostic biomarker for OA disease in pre- and post-menopausal women https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8808Coll2-1NO2, C-reactive protein, FSH, lipid profile, osteoarthritis |
| spellingShingle | Noor Basil Ghanim Bushra Faris Hasan Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis مجلة بغداد للعلوم Coll2-1NO2, C-reactive protein, FSH, lipid profile, osteoarthritis |
| title | Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis |
| title_full | Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis |
| title_fullStr | Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis |
| title_full_unstemmed | Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis |
| title_short | Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis |
| title_sort | evaluating coll2 1no2 level in pre and post menopausal iraqi women with osteoarthritis |
| topic | Coll2-1NO2, C-reactive protein, FSH, lipid profile, osteoarthritis |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8808 |
| work_keys_str_mv | AT noorbasilghanim evaluatingcoll21no2levelinpreandpostmenopausaliraqiwomenwithosteoarthritis AT bushrafarishasan evaluatingcoll21no2levelinpreandpostmenopausaliraqiwomenwithosteoarthritis |