Adipokine Contribution to the Pathogenesis of Osteoarthritis
Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5468023 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850174016300515328 |
|---|---|
| author | Daniel Azamar-Llamas Gabriela Hernández-Molina Bárbara Ramos-Ávalos Janette Furuzawa-Carballeda |
| author_facet | Daniel Azamar-Llamas Gabriela Hernández-Molina Bárbara Ramos-Ávalos Janette Furuzawa-Carballeda |
| author_sort | Daniel Azamar-Llamas |
| collection | DOAJ |
| description | Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies. |
| format | Article |
| id | doaj-art-c6c0f1313e914dd3aa7a7c6acbeef5f2 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c6c0f1313e914dd3aa7a7c6acbeef5f22025-08-20T02:19:44ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/54680235468023Adipokine Contribution to the Pathogenesis of OsteoarthritisDaniel Azamar-Llamas0Gabriela Hernández-Molina1Bárbara Ramos-Ávalos2Janette Furuzawa-Carballeda3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, 14080 Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, 14080 Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, 14080 Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, 14080 Mexico City, MexicoRecent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.http://dx.doi.org/10.1155/2017/5468023 |
| spellingShingle | Daniel Azamar-Llamas Gabriela Hernández-Molina Bárbara Ramos-Ávalos Janette Furuzawa-Carballeda Adipokine Contribution to the Pathogenesis of Osteoarthritis Mediators of Inflammation |
| title | Adipokine Contribution to the Pathogenesis of Osteoarthritis |
| title_full | Adipokine Contribution to the Pathogenesis of Osteoarthritis |
| title_fullStr | Adipokine Contribution to the Pathogenesis of Osteoarthritis |
| title_full_unstemmed | Adipokine Contribution to the Pathogenesis of Osteoarthritis |
| title_short | Adipokine Contribution to the Pathogenesis of Osteoarthritis |
| title_sort | adipokine contribution to the pathogenesis of osteoarthritis |
| url | http://dx.doi.org/10.1155/2017/5468023 |
| work_keys_str_mv | AT danielazamarllamas adipokinecontributiontothepathogenesisofosteoarthritis AT gabrielahernandezmolina adipokinecontributiontothepathogenesisofosteoarthritis AT barbararamosavalos adipokinecontributiontothepathogenesisofosteoarthritis AT janettefuruzawacarballeda adipokinecontributiontothepathogenesisofosteoarthritis |