A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

Thymus-committed regulatory T cells (Tregs) are essential for immune homeostasis. Recent findings stress their heterogeneity, suggesting possible alternate routes for thymic Treg development with unique features in humans, namely the clear evidence of Treg commitment at the double-positive (DP) stag...

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Bibliographic Details
Main Authors: Beatriz Moleirinho, Margarida Paulo-Pedro, Nicole C. Martins, Emily Jelagat, Eller Conti, Tiago R. Velho, Miguel Abecasis, Rui Anjos, Afonso R. M. Almeida, Ana E. Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
thymus
human immunology
regulatory T cells
T cell development
spectral flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553535/full
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