Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis
Acute pancreatitis (AP) is one of the gastrointestinal pathologies that most frequently requires hospital admission; about half of all deaths occur within the first two weeks and are caused by multi-organ failure. Predicting the degree of severity of AP before 48 h is a challenge. <b>Backgroun...
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MDPI AG
2025-05-01
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| Series: | Gastroenterology Insights |
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| Online Access: | https://www.mdpi.com/2036-7422/16/2/17 |
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| author | Oscar Francisco Iniestra-Ayllón José Antonio Morales-González Karina Sánchez-Reyes Elda Victoria Rodríguez-Negrete |
| author_facet | Oscar Francisco Iniestra-Ayllón José Antonio Morales-González Karina Sánchez-Reyes Elda Victoria Rodríguez-Negrete |
| author_sort | Oscar Francisco Iniestra-Ayllón |
| collection | DOAJ |
| description | Acute pancreatitis (AP) is one of the gastrointestinal pathologies that most frequently requires hospital admission; about half of all deaths occur within the first two weeks and are caused by multi-organ failure. Predicting the degree of severity of AP before 48 h is a challenge. <b>Background/Objectives</b>: Having an early marker, before 48 h after admission, could be useful to avoid or diagnose early complications such as organ failure (OF). A few sentences could place the question addressed in a broader context and highlight the purpose of the study. <b>Methods</b>: A retrospective study conducted in a third-level hospital, during the period from August 2019 to June 2021. Patients aged >18 years, with a diagnosis of PA, who had a complete clinical history and complete biochemical and imaging data were included. The scores of the APACHE II, BISAP, revised Atlanta classification, and modified Marshall scales were recorded. <b>Results</b>: Of the 103 patients included, 60% were women, the mean age was 47.76 years, and the hospital stay was 8 days (IQR 6–12); the most frequent etiology was biliary in 46 (44.7%) patients; the most frequent BMI was overweight with 34 (33%) patients; and 38 (36.9%) patients had a systemic inflammatory response at admission. Hypoalbuminemia was observed in 34 (33%) of the 103 patients at admission; of these, 42 (40.8%) had an APACHE II score > 8 points, 17 (16.3%) a BISAP score > 2, 57 (54.8%) patients were classified as moderate AP according to the revised Atlanta classification, and 54 patients had a score according to the modified Marshall score > 2. A statistically significant difference in the development of death was observed between patients with hypoalbuminemia versus those with normal serum albumin levels. <b>Conclusions</b>: In this study, we show the usefulness of hipoalbuminemia (<3.5 g/dL) at hospital admission in patients with AP, as a severity and mortality indicator. With the results obtained, we conclude that low albumin levels are a good predictor of severity and are useful for establishing timely treatment and close follow-up. |
| format | Article |
| id | doaj-art-c6bf224b3c604478bf2dc70d1750d979 |
| institution | Kabale University |
| issn | 2036-7414 2036-7422 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Gastroenterology Insights |
| spelling | doaj-art-c6bf224b3c604478bf2dc70d1750d9792025-08-20T03:27:10ZengMDPI AGGastroenterology Insights2036-74142036-74222025-05-011621710.3390/gastroent16020017Serum Albumin as an Early Predictor of Severity in Patients with Acute PancreatitisOscar Francisco Iniestra-Ayllón0José Antonio Morales-González1Karina Sánchez-Reyes2Elda Victoria Rodríguez-Negrete3Servicio de Gastroenterología, UMAE Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, Ciudad de México 06720, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, MexicoServicio de Cirugía Generla, UMAE Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, Ciudad de México 06720, MexicoServicio de Gastroenterología, UMAE Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, Ciudad de México 06720, MexicoAcute pancreatitis (AP) is one of the gastrointestinal pathologies that most frequently requires hospital admission; about half of all deaths occur within the first two weeks and are caused by multi-organ failure. Predicting the degree of severity of AP before 48 h is a challenge. <b>Background/Objectives</b>: Having an early marker, before 48 h after admission, could be useful to avoid or diagnose early complications such as organ failure (OF). A few sentences could place the question addressed in a broader context and highlight the purpose of the study. <b>Methods</b>: A retrospective study conducted in a third-level hospital, during the period from August 2019 to June 2021. Patients aged >18 years, with a diagnosis of PA, who had a complete clinical history and complete biochemical and imaging data were included. The scores of the APACHE II, BISAP, revised Atlanta classification, and modified Marshall scales were recorded. <b>Results</b>: Of the 103 patients included, 60% were women, the mean age was 47.76 years, and the hospital stay was 8 days (IQR 6–12); the most frequent etiology was biliary in 46 (44.7%) patients; the most frequent BMI was overweight with 34 (33%) patients; and 38 (36.9%) patients had a systemic inflammatory response at admission. Hypoalbuminemia was observed in 34 (33%) of the 103 patients at admission; of these, 42 (40.8%) had an APACHE II score > 8 points, 17 (16.3%) a BISAP score > 2, 57 (54.8%) patients were classified as moderate AP according to the revised Atlanta classification, and 54 patients had a score according to the modified Marshall score > 2. A statistically significant difference in the development of death was observed between patients with hypoalbuminemia versus those with normal serum albumin levels. <b>Conclusions</b>: In this study, we show the usefulness of hipoalbuminemia (<3.5 g/dL) at hospital admission in patients with AP, as a severity and mortality indicator. With the results obtained, we conclude that low albumin levels are a good predictor of severity and are useful for establishing timely treatment and close follow-up.https://www.mdpi.com/2036-7422/16/2/17acute pancreatitishypoalbumieminseverity stratificationprognosis |
| spellingShingle | Oscar Francisco Iniestra-Ayllón José Antonio Morales-González Karina Sánchez-Reyes Elda Victoria Rodríguez-Negrete Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis Gastroenterology Insights acute pancreatitis hypoalbumiemin severity stratification prognosis |
| title | Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis |
| title_full | Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis |
| title_fullStr | Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis |
| title_full_unstemmed | Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis |
| title_short | Serum Albumin as an Early Predictor of Severity in Patients with Acute Pancreatitis |
| title_sort | serum albumin as an early predictor of severity in patients with acute pancreatitis |
| topic | acute pancreatitis hypoalbumiemin severity stratification prognosis |
| url | https://www.mdpi.com/2036-7422/16/2/17 |
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