Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies
Background: Prostate-specific antigen density has been suggested to enhance the diagnostic efficacy of serum prostate-specific antigen alone in detecting prostate cancer, thereby reducing unnecessary biopsies and associated morbidities. This study aimed to assess the diagnostic performance of prosta...
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Association of Clinical Pathologists of Nepal
2022-03-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/41841 |
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| author | Reshmi Shrestha Shova Kunwar Suman Gurung Anjana Nuri Pokharel |
| author_facet | Reshmi Shrestha Shova Kunwar Suman Gurung Anjana Nuri Pokharel |
| author_sort | Reshmi Shrestha |
| collection | DOAJ |
| description | Background: Prostate-specific antigen density has been suggested to enhance the diagnostic efficacy of serum prostate-specific antigen alone in detecting prostate cancer, thereby reducing unnecessary biopsies and associated morbidities. This study aimed to assess the diagnostic performance of prostate-specific antigen density in detecting prostate cancer.
Materials and methods: A retrospective analysis of histologically proven benign and malignant prostate diseases, submitted in the histopathology department was performed from April 2019 to March 2020. The diagnostic performance of prostate-specific antigen density was assessed and its optimum cut-off value was determined using the receiver operating characteristic curves. The diagnostic efficacy of prostate-specific antigen density was also compared with prostate-specific antigen in detecting prostate cancer.
Results: The AUC to predict prostate cancer was 0.89 (95% CI 0.79-0.98. p <0.001) for prostate-specific antigen density. The diagnostic performance of prostate-specific antigen density at cut-off 0.18 ng/ml/cc was better than prostate-specific antigen alone (AUC, 0.838 vs 0.662). Sensitivity was 80% for both prostate-specific antigen density at cut-off 0.18 ng/ml/cc and prostate-specific antigen. But, prostate-specific antigen density had a higher specificity of 87.7 % than prostate-specific antigen (52.3%)and thus it could better distinguish benign diseases from prostate cancer. It would have reduced unnecessary biopsy by 35%.
Conclusions: The diagnostic efficacy of prostate-specific antigen density was good and it was found to be a better predictor of prostate cancer at the cut-off value of 0.18ng/ml/cc when compared to prostate-specific antigen alone. |
| format | Article |
| id | doaj-art-c6bd952723f545eb855104ba42e3fe1b |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-c6bd952723f545eb855104ba42e3fe1b2025-08-21T07:06:58ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082022-03-011211907191310.3126/jpn.v12i1.4184168891Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsiesReshmi Shrestha0https://orcid.org/0000-0002-9914-9213Shova Kunwar1Suman Gurung2Anjana Nuri Pokharel3Nepalese Army Institute of Health Sciences, Kathmandu, Nepal, Sanobharyang, Kathmandu, NepalNepalese Army Institute of Health Sciences, Shree Birendra Hospital, Kathmandu NepalNepalese Army Institute of Health Sciences, Shree Birendra Hospital, Kathmandu NepalNepalese Army Institute of Health Sciences, Shree Birendra Hospital, Kathmandu NepalBackground: Prostate-specific antigen density has been suggested to enhance the diagnostic efficacy of serum prostate-specific antigen alone in detecting prostate cancer, thereby reducing unnecessary biopsies and associated morbidities. This study aimed to assess the diagnostic performance of prostate-specific antigen density in detecting prostate cancer. Materials and methods: A retrospective analysis of histologically proven benign and malignant prostate diseases, submitted in the histopathology department was performed from April 2019 to March 2020. The diagnostic performance of prostate-specific antigen density was assessed and its optimum cut-off value was determined using the receiver operating characteristic curves. The diagnostic efficacy of prostate-specific antigen density was also compared with prostate-specific antigen in detecting prostate cancer. Results: The AUC to predict prostate cancer was 0.89 (95% CI 0.79-0.98. p <0.001) for prostate-specific antigen density. The diagnostic performance of prostate-specific antigen density at cut-off 0.18 ng/ml/cc was better than prostate-specific antigen alone (AUC, 0.838 vs 0.662). Sensitivity was 80% for both prostate-specific antigen density at cut-off 0.18 ng/ml/cc and prostate-specific antigen. But, prostate-specific antigen density had a higher specificity of 87.7 % than prostate-specific antigen (52.3%)and thus it could better distinguish benign diseases from prostate cancer. It would have reduced unnecessary biopsy by 35%. Conclusions: The diagnostic efficacy of prostate-specific antigen density was good and it was found to be a better predictor of prostate cancer at the cut-off value of 0.18ng/ml/cc when compared to prostate-specific antigen alone.https://www.nepjol.info/index.php/JPN/article/view/41841cancer; prostate; prostate-specific antigen; prostate-specific antigen density |
| spellingShingle | Reshmi Shrestha Shova Kunwar Suman Gurung Anjana Nuri Pokharel Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies Journal of Pathology of Nepal cancer; prostate; prostate-specific antigen; prostate-specific antigen density |
| title | Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies |
| title_full | Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies |
| title_fullStr | Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies |
| title_full_unstemmed | Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies |
| title_short | Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies |
| title_sort | usefulness of prostate specific antigen density in detecting prostate carcinoma a hospital based study in patients with prostate biopsies |
| topic | cancer; prostate; prostate-specific antigen; prostate-specific antigen density |
| url | https://www.nepjol.info/index.php/JPN/article/view/41841 |
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