Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

<h4>Background</h4>Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is...

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Main Authors: Soo-Yon Rhee, Jose Luis Blanco, Michael R Jordan, Jonathan Taylor, Philippe Lemey, Vici Varghese, Raph L Hamers, Silvia Bertagnolio, Tobias F Rinke de Wit, Avelin F Aghokeng, Jan Albert, Radko Avi, Santiago Avila-Rios, Pascal O Bessong, James I Brooks, Charles A B Boucher, Zabrina L Brumme, Michael P Busch, Hermann Bussmann, Marie-Laure Chaix, Bum Sik Chin, Toni T D'Aquin, Cillian F De Gascun, Anne Derache, Diane Descamps, Alaka K Deshpande, Cyrille F Djoko, Susan H Eshleman, Herve Fleury, Pierre Frange, Seiichiro Fujisaki, P Richard Harrigan, Junko Hattori, Africa Holguin, Gillian M Hunt, Hiroshi Ichimura, Pontiano Kaleebu, David Katzenstein, Sasisopin Kiertiburanakul, Jerome H Kim, Sung Soon Kim, Yanpeng Li, Irja Lutsar, Lynn Morris, Nicaise Ndembi, Kee Peng Ng, Ramesh S Paranjape, Martine Peeters, Mario Poljak, Matt A Price, Manon L Ragonnet-Cronin, Gustavo Reyes-Terán, Morgane Rolland, Sunee Sirivichayakul, Davey M Smith, Marcelo A Soares, Vincent V Soriano, Deogratius Ssemwanga, Maja Stanojevic, Mariane A Stefani, Wataru Sugiura, Somnuek Sungkanuparph, Amilcar Tanuri, Kok Keng Tee, Hong-Ha M Truong, David A M C van de Vijver, Nicole Vidal, Chunfu Yang, Rongge Yang, Gonzalo Yebra, John P A Ioannidis, Anne-Mieke Vandamme, Robert W Shafer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001810
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https://doi.org/10.1371/journal.pmed.1001810

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