The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which remains a global health challenge, with an estimated incidence of more than 1 million cases by 2025. The current major progress has improved the management of patients with advanced disease. Systemic treatments with mu...
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| Format: | Article |
| Language: | English |
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THE HEALTHBOOK COMPANY LTD.
2021-12-01
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| Series: | healthbook TIMES. Oncology Hematology |
| Online Access: | https://doi.org/10.36000/hbT.OH.2021.10.057 |
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| _version_ | 1850257114536083456 |
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| author | Sara De Dosso Marco Cefali Maria Celeste Palmarocchi |
| author_facet | Sara De Dosso Marco Cefali Maria Celeste Palmarocchi |
| author_sort | Sara De Dosso |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which remains a global health challenge, with an estimated incidence of more than 1 million cases by 2025. The current major progress has improved the management of patients with advanced disease. Systemic treatments with multitarget agents, antiangiogenics alone or in combination with an immune checkpoint inhibitor (ICI), have been approved following positive results from phase III clinical studies. Several ongoing trials are currently exploring novel combinations and are expected to further change the HCC treatment landscape. In this review, we present all approved targeted agents for advanced HCC with an emphasis on their clinical efficacy and discuss the exciting results of the combination of targeted therapy and ICI. Finally, we also summarize the advances in clinical research for HCC. |
| format | Article |
| id | doaj-art-c6b173a0447f44e89d73f70045ee1ed1 |
| institution | OA Journals |
| issn | 2673-2092 2673-2106 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | THE HEALTHBOOK COMPANY LTD. |
| record_format | Article |
| series | healthbook TIMES. Oncology Hematology |
| spelling | doaj-art-c6b173a0447f44e89d73f70045ee1ed12025-08-20T01:56:29ZengTHE HEALTHBOOK COMPANY LTD.healthbook TIMES. Oncology Hematology2673-20922673-21062021-12-0110410.36000/hbT.OH.2021.10.057The Evolving Systemic Treatment for Advanced Hepatocellular CarcinomaSara De DossoMarco CefaliMaria Celeste PalmarocchiHepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which remains a global health challenge, with an estimated incidence of more than 1 million cases by 2025. The current major progress has improved the management of patients with advanced disease. Systemic treatments with multitarget agents, antiangiogenics alone or in combination with an immune checkpoint inhibitor (ICI), have been approved following positive results from phase III clinical studies. Several ongoing trials are currently exploring novel combinations and are expected to further change the HCC treatment landscape. In this review, we present all approved targeted agents for advanced HCC with an emphasis on their clinical efficacy and discuss the exciting results of the combination of targeted therapy and ICI. Finally, we also summarize the advances in clinical research for HCC.https://doi.org/10.36000/hbT.OH.2021.10.057 |
| spellingShingle | Sara De Dosso Marco Cefali Maria Celeste Palmarocchi The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma healthbook TIMES. Oncology Hematology |
| title | The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma |
| title_full | The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma |
| title_fullStr | The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma |
| title_full_unstemmed | The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma |
| title_short | The Evolving Systemic Treatment for Advanced Hepatocellular Carcinoma |
| title_sort | evolving systemic treatment for advanced hepatocellular carcinoma |
| url | https://doi.org/10.36000/hbT.OH.2021.10.057 |
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