Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
Purpose. To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods. Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional s...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6830671 |
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| author | Thunyarat Anothaisintawee Dumrongrat Lertrattananon Sangsulee Thamakaison Sirimon Reutrakul Boonsong Ongphiphadhanakul Ammarin Thakkinstian |
| author_facet | Thunyarat Anothaisintawee Dumrongrat Lertrattananon Sangsulee Thamakaison Sirimon Reutrakul Boonsong Ongphiphadhanakul Ammarin Thakkinstian |
| author_sort | Thunyarat Anothaisintawee |
| collection | DOAJ |
| description | Purpose. To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods. Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC). A mediation effect was estimated using the product-of-coefficient method with a bootstrap analysis of 1000 replications. Results. 1043 patients were eligible for this study. Every 1 mg/dl increase in SUA was associated with an increase in WC and then was significantly associated with an increase in FPG by 0.082 mg/dl (95% CI: 0.010, 0.154). SUA was directly associated with FPG with a coefficient of 0.413 (95% CI: 0.049, 0.776). For HbA1c, every one mg/dl increase in SUA was associated with an increase in HbA1c level through WC by 0.006 (95% CI: 0.003, 0.010). However, SUA was not directly associated with HbA1c. Conclusions. We found that an increase in SUA was directly and indirectly associated with increased FPG but the effect of SUA on HbA1c was shown when it was mediated through WC. |
| format | Article |
| id | doaj-art-c6b10df3dcb944fb8e7e10868779e761 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c6b10df3dcb944fb8e7e10868779e7612025-08-20T02:19:41ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/68306716830671Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation AnalysisThunyarat Anothaisintawee0Dumrongrat Lertrattananon1Sangsulee Thamakaison2Sirimon Reutrakul3Boonsong Ongphiphadhanakul4Ammarin Thakkinstian5Department of Family Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahdiol University, Bangkok, ThailandDepartment of Family Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahdiol University, Bangkok, ThailandDepartment of Family Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahdiol University, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandPurpose. To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods. Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC). A mediation effect was estimated using the product-of-coefficient method with a bootstrap analysis of 1000 replications. Results. 1043 patients were eligible for this study. Every 1 mg/dl increase in SUA was associated with an increase in WC and then was significantly associated with an increase in FPG by 0.082 mg/dl (95% CI: 0.010, 0.154). SUA was directly associated with FPG with a coefficient of 0.413 (95% CI: 0.049, 0.776). For HbA1c, every one mg/dl increase in SUA was associated with an increase in HbA1c level through WC by 0.006 (95% CI: 0.003, 0.010). However, SUA was not directly associated with HbA1c. Conclusions. We found that an increase in SUA was directly and indirectly associated with increased FPG but the effect of SUA on HbA1c was shown when it was mediated through WC.http://dx.doi.org/10.1155/2017/6830671 |
| spellingShingle | Thunyarat Anothaisintawee Dumrongrat Lertrattananon Sangsulee Thamakaison Sirimon Reutrakul Boonsong Ongphiphadhanakul Ammarin Thakkinstian Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis Journal of Diabetes Research |
| title | Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis |
| title_full | Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis |
| title_fullStr | Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis |
| title_full_unstemmed | Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis |
| title_short | Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis |
| title_sort | direct and indirect effects of serum uric acid on blood sugar levels in patients with prediabetes a mediation analysis |
| url | http://dx.doi.org/10.1155/2017/6830671 |
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