Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration
Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, gene...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/761393 |
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| author | Nicolas De Schryver Xavier Wittebole Peter Van den Bergh Vincent Haufroid Eric Goffin Philippe Hantson |
| author_facet | Nicolas De Schryver Xavier Wittebole Peter Van den Bergh Vincent Haufroid Eric Goffin Philippe Hantson |
| author_sort | Nicolas De Schryver |
| collection | DOAJ |
| description | Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination. |
| format | Article |
| id | doaj-art-c6aad163512a40a89b8195895be408d9 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-c6aad163512a40a89b8195895be408d92025-02-03T01:01:57ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/761393761393Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine CoadministrationNicolas De Schryver0Xavier Wittebole1Peter Van den Bergh2Vincent Haufroid3Eric Goffin4Philippe Hantson5Department of Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumCentre de Référence Neuromusculaire, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumLouvain Centre for Toxicology and Applied Pharmacology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumSimvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination.http://dx.doi.org/10.1155/2015/761393 |
| spellingShingle | Nicolas De Schryver Xavier Wittebole Peter Van den Bergh Vincent Haufroid Eric Goffin Philippe Hantson Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration Case Reports in Nephrology |
| title | Severe Rhabdomyolysis Associated with Simvastatin and Role of
Ciprofloxacin and Amlodipine Coadministration |
| title_full | Severe Rhabdomyolysis Associated with Simvastatin and Role of
Ciprofloxacin and Amlodipine Coadministration |
| title_fullStr | Severe Rhabdomyolysis Associated with Simvastatin and Role of
Ciprofloxacin and Amlodipine Coadministration |
| title_full_unstemmed | Severe Rhabdomyolysis Associated with Simvastatin and Role of
Ciprofloxacin and Amlodipine Coadministration |
| title_short | Severe Rhabdomyolysis Associated with Simvastatin and Role of
Ciprofloxacin and Amlodipine Coadministration |
| title_sort | severe rhabdomyolysis associated with simvastatin and role of ciprofloxacin and amlodipine coadministration |
| url | http://dx.doi.org/10.1155/2015/761393 |
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