Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
A notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing to drug resistance include drug efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, and the tumor microenvironment, among othe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548588/full |
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| _version_ | 1849310688127746048 |
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| author | Shazia Sabir Ali Salman Bin Thani Qamar Abbas |
| author_facet | Shazia Sabir Ali Salman Bin Thani Qamar Abbas |
| author_sort | Shazia Sabir |
| collection | DOAJ |
| description | A notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing to drug resistance include drug efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, and the tumor microenvironment, among others. Systemic toxicities and resistance associated with conventional cancer diagnostics and therapies have led to the development of alternative approaches, such as nanotechnology, to enhance diagnostic precision and improve therapeutic outcomes. Nanomaterial, including carbon nanotubes, dendrimers, polymeric micelles, and liposomes, have shown significant benefits in cancer diagnosis and treatment due to their unique physicochemical properties, such as biocompatibility, stability, enhanced permeability, retention characteristics, and targeted delivery. Building on these advantages, this review is conducted through comprehensive analysis of recent literature to explore the principal mechanisms of drug resistance, the potential of nanomaterials to revolutionize selective drug delivery and cancer treatment. Additionally, the strategies employed by nanomaterials to overcome drug resistance in tumors, such as efflux pump inhibition, multidrug loading, targeted delivery to the tumor microenvironment, and gene silencing therapies are discussed in detail. Furthermore, we examine the challenges associated with nanomaterials that limit their application and impede their transition to clinical use. |
| format | Article |
| id | doaj-art-c6aa380f2ef246b096baac7d06ab30cf |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-c6aa380f2ef246b096baac7d06ab30cf2025-08-20T03:53:39ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-04-011310.3389/fbioe.2025.15485881548588Nanotechnology in cancer treatment: revolutionizing strategies against drug resistanceShazia SabirAli Salman Bin ThaniQamar AbbasA notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing to drug resistance include drug efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, and the tumor microenvironment, among others. Systemic toxicities and resistance associated with conventional cancer diagnostics and therapies have led to the development of alternative approaches, such as nanotechnology, to enhance diagnostic precision and improve therapeutic outcomes. Nanomaterial, including carbon nanotubes, dendrimers, polymeric micelles, and liposomes, have shown significant benefits in cancer diagnosis and treatment due to their unique physicochemical properties, such as biocompatibility, stability, enhanced permeability, retention characteristics, and targeted delivery. Building on these advantages, this review is conducted through comprehensive analysis of recent literature to explore the principal mechanisms of drug resistance, the potential of nanomaterials to revolutionize selective drug delivery and cancer treatment. Additionally, the strategies employed by nanomaterials to overcome drug resistance in tumors, such as efflux pump inhibition, multidrug loading, targeted delivery to the tumor microenvironment, and gene silencing therapies are discussed in detail. Furthermore, we examine the challenges associated with nanomaterials that limit their application and impede their transition to clinical use.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548588/fullnanoparticlesnanomaterialsdrug deliverytargeted strategiesnanotechnologycancer |
| spellingShingle | Shazia Sabir Ali Salman Bin Thani Qamar Abbas Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance Frontiers in Bioengineering and Biotechnology nanoparticles nanomaterials drug delivery targeted strategies nanotechnology cancer |
| title | Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance |
| title_full | Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance |
| title_fullStr | Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance |
| title_full_unstemmed | Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance |
| title_short | Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance |
| title_sort | nanotechnology in cancer treatment revolutionizing strategies against drug resistance |
| topic | nanoparticles nanomaterials drug delivery targeted strategies nanotechnology cancer |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1548588/full |
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