Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

Summary: Persons with neurofibromatosis type 1 (NF1) exhibit enhanced glucose metabolism, which is replicated in Nf1-mutant mice. Inflammatory macrophages invest NF1-associated tumors, and targeting macrophages appears efficacious in NF1 models. Inflammatory macrophages rely on glycolysis to generat...

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Main Authors: Yusra Zaidi, Rebekah Tritz, Nida Zaidi, Faisal Nabi, Syed Adeel H. Zaidi, Abdelhakim Morsy, Valerie Harris, Rilee Racine, Farlyn Z. Hudson, Zsuzsanna Bordan, Simone Kennard, Robert Batori, Yuqing Huo, Gabor Csanyi, Eric J. Belin de Chantemèle, Kecheng Lei, Nicholas M. Boulis, David J. Fulton, Rizwan Hasan Khan, Ruth B. Caldwell, Brian K. Stansfield
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003961
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