Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.
Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inocu...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171148&type=printable |
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| author | Lark L Coffey Patricia A Pesavento Rebekah I Keesler Anil Singapuri Jennifer Watanabe Rie Watanabe JoAnn Yee Eliza Bliss-Moreau Christina Cruzen Kari L Christe J Rachel Reader Wilhelm von Morgenland Anne M Gibbons A Mark Allen Jeff Linnen Kui Gao Eric Delwart Graham Simmons Mars Stone Marion Lanteri Sonia Bakkour Michael Busch John Morrison Koen K A Van Rompay |
| author_facet | Lark L Coffey Patricia A Pesavento Rebekah I Keesler Anil Singapuri Jennifer Watanabe Rie Watanabe JoAnn Yee Eliza Bliss-Moreau Christina Cruzen Kari L Christe J Rachel Reader Wilhelm von Morgenland Anne M Gibbons A Mark Allen Jeff Linnen Kui Gao Eric Delwart Graham Simmons Mars Stone Marion Lanteri Sonia Bakkour Michael Busch John Morrison Koen K A Van Rompay |
| author_sort | Lark L Coffey |
| collection | DOAJ |
| description | Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed. In 1 animal, viral RNA (vRNA) could be detected longer in whole blood than in plasma. Despite no major histopathologic changes, many adult tissues contained vRNA 14 days post-infection with highest levels in hemolymphatic tissues. These observations warrant further studies to investigate ZIKV persistence and its potential clinical implications for transmission via blood products or tissue and organ transplants. |
| format | Article |
| id | doaj-art-c69f8eb9be6748fb943c62f406efbf0f |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c69f8eb9be6748fb943c62f406efbf0f2025-08-20T03:04:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e017114810.1371/journal.pone.0171148Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.Lark L CoffeyPatricia A PesaventoRebekah I KeeslerAnil SingapuriJennifer WatanabeRie WatanabeJoAnn YeeEliza Bliss-MoreauChristina CruzenKari L ChristeJ Rachel ReaderWilhelm von MorgenlandAnne M GibbonsA Mark AllenJeff LinnenKui GaoEric DelwartGraham SimmonsMars StoneMarion LanteriSonia BakkourMichael BuschJohn MorrisonKoen K A Van RompayAnimal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed. In 1 animal, viral RNA (vRNA) could be detected longer in whole blood than in plasma. Despite no major histopathologic changes, many adult tissues contained vRNA 14 days post-infection with highest levels in hemolymphatic tissues. These observations warrant further studies to investigate ZIKV persistence and its potential clinical implications for transmission via blood products or tissue and organ transplants.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171148&type=printable |
| spellingShingle | Lark L Coffey Patricia A Pesavento Rebekah I Keesler Anil Singapuri Jennifer Watanabe Rie Watanabe JoAnn Yee Eliza Bliss-Moreau Christina Cruzen Kari L Christe J Rachel Reader Wilhelm von Morgenland Anne M Gibbons A Mark Allen Jeff Linnen Kui Gao Eric Delwart Graham Simmons Mars Stone Marion Lanteri Sonia Bakkour Michael Busch John Morrison Koen K A Van Rompay Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. PLoS ONE |
| title | Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. |
| title_full | Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. |
| title_fullStr | Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. |
| title_full_unstemmed | Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. |
| title_short | Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques. |
| title_sort | zika virus tissue and blood compartmentalization in acute infection of rhesus macaques |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171148&type=printable |
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