Normal tissue radioprotection by amifostine via Warburg-type effects

Normal tissue radioprotection by amifostine via Warburg-type effects

Abstract The mechanism of Amifostine (WR-2721) mediated radioprotection is poorly understood. The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. Indirect calorimetric canopy tests showed significant reductions in oxygen con...

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Main Authors: Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris
Format: Article
Language:English
Published: Nature Portfolio 2016-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/srep30986
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