Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation

Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) has led to significant economic losses in the global swine industry. Type I interferon (IFN-I) plays a crucial role in the host’s resistance to PRRSV infection. Despite extensive research showing that PRRSV employs multiple strateg...

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Bibliographic Details
Main Authors: Shuang-shuang Zhao, Qisheng Qian, Yao Wang, Songlin Qiao, Rui Li
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Veterinary Research
Subjects:
PRRSV
Nsp2
TBK1
IFN-I
CMA
Online Access:https://doi.org/10.1186/s13567-024-01392-w
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