Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response

Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response

Abstract HIV-1 Env glycoprotein (Env) immunogenicity is limited in part by structural instability and extensive glycan shielding and is likely the greatest obstacle to an HIV-1 vaccine. Stabilized Env trimers can elicit serum neutralizing antibodies, but the response is short-lived. Here we use Newc...

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Main Authors: Kenta Matsuda, Mitra Harrison, Eleanor Wettstein, Jessica Pederson, Alyssa A. Pullano, Lyuba Bolkhovitinov, Breanna Kim, Isabel Steinberg, Trevor Griesman, Sarah Stuccio, Daniel Rogan, Andy Patamawenu, Tulley Shofner, Nathaniel E. Wright, Jonathan D. Webber, Freya van’t Veer, Rachel Roenicke, Emma Koory, Peyton M. Roeder, Ellison Ober, Benjamin Leach, Yaroslav Tsybovsky, Tyler Stephens, Ivan Del Moral-Sanchez, Ilja Bontjer, Lori W. McGinnes-Cullen, Eric Chu, Jason Liang, Jonathan L. Torres, Ryan N. Lin, Andy S. Tran, Gabrielle Dziubla, Leonid Serebryannyy, Sandeep Narpala, Bob Lin, Mike Castro, Gabriel Ozorowski, Andrew B. Ward, Rogier W. Sanders, Peter D. Kwong, Javier Guenaga, Richard Wyatt, Trudy Morrison, Mark Connors
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60481-2
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