Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis
IgA vasculitis (formerly known as Henoch–Schönlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2020/8867621 |
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| author | George Naifa George Totikidis Sonia Alexiadou Christina Kolona Elpis Mantadakis |
| author_facet | George Naifa George Totikidis Sonia Alexiadou Christina Kolona Elpis Mantadakis |
| author_sort | George Naifa |
| collection | DOAJ |
| description | IgA vasculitis (formerly known as Henoch–Schönlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is mainly supportive, with administration of simple analgesics. Corticosteroids have been shown to reduce and/or ameliorate the occurrence of abdominal pain which may be severe. We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous γ globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis. |
| format | Article |
| id | doaj-art-c68e2bb0c40e4039af97b0823b597b97 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-c68e2bb0c40e4039af97b0823b597b972025-02-03T01:28:09ZengWileyCase Reports in Pediatrics2090-68032090-68112020-01-01202010.1155/2020/88676218867621Intravenous γ Globulin for Intractable Abdominal Pain due to IgA VasculitisGeorge Naifa0George Totikidis1Sonia Alexiadou2Christina Kolona3Elpis Mantadakis4Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, GreeceNHS Registra in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, GreeceResident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, GreeceResident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, GreecePediatrics-Pediatric Hematology/Oncology, Democritus University of Thrace Faculty of Medicine, Alexandroupoli, Thrace, GreeceIgA vasculitis (formerly known as Henoch–Schönlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is mainly supportive, with administration of simple analgesics. Corticosteroids have been shown to reduce and/or ameliorate the occurrence of abdominal pain which may be severe. We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous γ globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.http://dx.doi.org/10.1155/2020/8867621 |
| spellingShingle | George Naifa George Totikidis Sonia Alexiadou Christina Kolona Elpis Mantadakis Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis Case Reports in Pediatrics |
| title | Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis |
| title_full | Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis |
| title_fullStr | Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis |
| title_full_unstemmed | Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis |
| title_short | Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis |
| title_sort | intravenous γ globulin for intractable abdominal pain due to iga vasculitis |
| url | http://dx.doi.org/10.1155/2020/8867621 |
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