Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment
With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors. However, unlike active targeting, the complex tumor microenvironment influences the passive accumulation of nanoparticle...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S295048992400023X |
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| author | Yun Yin Xiaoyang Liu Xuemei Li Gaolin Liang |
| author_facet | Yun Yin Xiaoyang Liu Xuemei Li Gaolin Liang |
| author_sort | Yun Yin |
| collection | DOAJ |
| description | With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors. However, unlike active targeting, the complex tumor microenvironment influences the passive accumulation of nanoparticles in tumor areas. Hence, it is necessary to actively control the behavior of nanoparticles when they enter the tumor microenvironment. By utilizing biocompatible and efficient click reactions, the aggregation of nanoparticles at the tumor site can be controlled, thereby enhancing nanoparticle accumulation at the target location with improved imaging signals and enhanced tumor-inhibitory effects. Herein, we introduce and classify in situ nanoparticle aggregation for biomedical imaging and therapeutic applications induced by four types of common click reactions: copper-catalyzed azide–alkyne cycloaddition (CuAAC), strain-promoted azide–alkyne cycloaddition (SPAAC), click condensation between 2-cyanobenzothiazole (CBT) and cysteine (Cys), and inverse electron-demand Diels–Alder (iEDDA). Furthermore, we summarize the main strategies of these click reaction-based nanoparticle aggregation approaches. Finally, we discuss the advantages and disadvantages of click reaction-triggered aggregation and analyze future trends. |
| format | Article |
| id | doaj-art-c68dfab097fc4b19999d411874b3ff2e |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-c68dfab097fc4b19999d411874b3ff2e2025-01-11T06:42:28ZengElsevierEngMedicine2950-48992024-09-0112100023Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatmentYun Yin0Xiaoyang Liu1Xuemei Li2Gaolin Liang3Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, ChinaState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing 211189, ChinaCollaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China; Corresponding author.State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing 211189, China; Handan Norman Technology Co., Ltd., Guantao 057750, China; Corresponding author. State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing 211189, China.With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors. However, unlike active targeting, the complex tumor microenvironment influences the passive accumulation of nanoparticles in tumor areas. Hence, it is necessary to actively control the behavior of nanoparticles when they enter the tumor microenvironment. By utilizing biocompatible and efficient click reactions, the aggregation of nanoparticles at the tumor site can be controlled, thereby enhancing nanoparticle accumulation at the target location with improved imaging signals and enhanced tumor-inhibitory effects. Herein, we introduce and classify in situ nanoparticle aggregation for biomedical imaging and therapeutic applications induced by four types of common click reactions: copper-catalyzed azide–alkyne cycloaddition (CuAAC), strain-promoted azide–alkyne cycloaddition (SPAAC), click condensation between 2-cyanobenzothiazole (CBT) and cysteine (Cys), and inverse electron-demand Diels–Alder (iEDDA). Furthermore, we summarize the main strategies of these click reaction-based nanoparticle aggregation approaches. Finally, we discuss the advantages and disadvantages of click reaction-triggered aggregation and analyze future trends.http://www.sciencedirect.com/science/article/pii/S295048992400023XAggregationCancerClick reactionsImaging and treatmentNanoparticlesPre-targeting |
| spellingShingle | Yun Yin Xiaoyang Liu Xuemei Li Gaolin Liang Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment EngMedicine Aggregation Cancer Click reactions Imaging and treatment Nanoparticles Pre-targeting |
| title | Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment |
| title_full | Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment |
| title_fullStr | Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment |
| title_full_unstemmed | Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment |
| title_short | Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment |
| title_sort | click reaction induced in situ nanoparticle aggregation for cancer imaging and treatment |
| topic | Aggregation Cancer Click reactions Imaging and treatment Nanoparticles Pre-targeting |
| url | http://www.sciencedirect.com/science/article/pii/S295048992400023X |
| work_keys_str_mv | AT yunyin clickreactioninducedinsitunanoparticleaggregationforcancerimagingandtreatment AT xiaoyangliu clickreactioninducedinsitunanoparticleaggregationforcancerimagingandtreatment AT xuemeili clickreactioninducedinsitunanoparticleaggregationforcancerimagingandtreatment AT gaolinliang clickreactioninducedinsitunanoparticleaggregationforcancerimagingandtreatment |