Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis
Background: Identification of new biomarkers for acute deep vein thrombosis (DVT) that could lower the need for diagnostic imaging to confirm or rule out the diagnosis would be advantageous. microRNA-145-5p (miR-145) has the potential to be a diagnostic marker for acute DVT, but its diagnostic perfo...
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| Format: | Article |
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Elsevier
2025-01-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2475037924003662 |
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| author | Christopher Antoun Vårin Eiriksdatter Wikan Øyvind Øverli Thor Ueland Gholamreza Jafari Yeganeh Sigrid Kufaas Brækkan Ellen Brodin John-Bjarne Hansen |
| author_facet | Christopher Antoun Vårin Eiriksdatter Wikan Øyvind Øverli Thor Ueland Gholamreza Jafari Yeganeh Sigrid Kufaas Brækkan Ellen Brodin John-Bjarne Hansen |
| author_sort | Christopher Antoun |
| collection | DOAJ |
| description | Background: Identification of new biomarkers for acute deep vein thrombosis (DVT) that could lower the need for diagnostic imaging to confirm or rule out the diagnosis would be advantageous. microRNA-145-5p (miR-145) has the potential to be a diagnostic marker for acute DVT, but its diagnostic performance has not been evaluated in consecutive patients referred to the hospital with suspected DVT. Objectives: The aim of this study was to assess the diagnostic performance of miR-145 for the diagnosis of acute lower extremity DVT. Methods: Patients consecutively referred to the emergency room at Akershus University Hospital (Norway) due to suspicion of acute DVT between June 2021 and July 2023 were included. Within 24 hours of admission, blood was collected for assessment of plasma miR-145 (index test), and whole-leg compression ultrasound (reference standard) was used to confirm or rule out DVT. Cohen’s d effect size and area under the receiver operating curve (AUC) were used to estimate the diagnostic performance of miR-145 and D-dimer. Results: Among 360 included patients, 101 (28%) were diagnosed with DVT. miR-145 showed poor diagnostic performance, as indicated by a Cohen’s d of −0.002 (95% CI, −0.241 to 0.216) and an AUC of 0.59 (95% CI, 0.51-0.67). For D-dimer, Cohen’s d was 1.66 (95% CI, 1.43-1.89), and the AUC was 0.92 (95% CI, 0.86-0.96). Conclusion: Plasma levels of miR-145 showed poor diagnostic performance for lower extremity acute DVT among persons referred to the emergency room with clinical signs and symptoms of DVT. |
| format | Article |
| id | doaj-art-c688175269574058b0ad11b70905d7da |
| institution | Kabale University |
| issn | 2475-0379 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj-art-c688175269574058b0ad11b70905d7da2025-01-22T05:43:06ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792025-01-0191102671Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosisChristopher Antoun0Vårin Eiriksdatter Wikan1Øyvind Øverli2Thor Ueland3Gholamreza Jafari Yeganeh4Sigrid Kufaas Brækkan5Ellen Brodin6John-Bjarne Hansen7Thrombosis Research Group, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway; Correspondence Christopher Antoun, Thrombosis Research Group, Department of Clinical Medicine, UiT–The Arctic University of Tromsø, 9037, Tromsø, Norway.Thrombosis Research Group, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, NorwayDivision of Internal Medicine, Department of Haematology, Akershus University Hospital, Lørenskog, NorwayDivision of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Emergency Medicine, Akershus University Hospital, Lørenskog, NorwayThrombosis Research Group, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway; Division of Internal Medicine, University Hospital of North Norway, Tromsø, NorwayDivision of Internal Medicine, Department of Haematology, Akershus University Hospital, Lørenskog, NorwayThrombosis Research Group, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway; Division of Internal Medicine, University Hospital of North Norway, Tromsø, NorwayBackground: Identification of new biomarkers for acute deep vein thrombosis (DVT) that could lower the need for diagnostic imaging to confirm or rule out the diagnosis would be advantageous. microRNA-145-5p (miR-145) has the potential to be a diagnostic marker for acute DVT, but its diagnostic performance has not been evaluated in consecutive patients referred to the hospital with suspected DVT. Objectives: The aim of this study was to assess the diagnostic performance of miR-145 for the diagnosis of acute lower extremity DVT. Methods: Patients consecutively referred to the emergency room at Akershus University Hospital (Norway) due to suspicion of acute DVT between June 2021 and July 2023 were included. Within 24 hours of admission, blood was collected for assessment of plasma miR-145 (index test), and whole-leg compression ultrasound (reference standard) was used to confirm or rule out DVT. Cohen’s d effect size and area under the receiver operating curve (AUC) were used to estimate the diagnostic performance of miR-145 and D-dimer. Results: Among 360 included patients, 101 (28%) were diagnosed with DVT. miR-145 showed poor diagnostic performance, as indicated by a Cohen’s d of −0.002 (95% CI, −0.241 to 0.216) and an AUC of 0.59 (95% CI, 0.51-0.67). For D-dimer, Cohen’s d was 1.66 (95% CI, 1.43-1.89), and the AUC was 0.92 (95% CI, 0.86-0.96). Conclusion: Plasma levels of miR-145 showed poor diagnostic performance for lower extremity acute DVT among persons referred to the emergency room with clinical signs and symptoms of DVT.http://www.sciencedirect.com/science/article/pii/S2475037924003662biomarkercross-sectional studiesdeep vein thrombosisdiagnosismicroRNApatients |
| spellingShingle | Christopher Antoun Vårin Eiriksdatter Wikan Øyvind Øverli Thor Ueland Gholamreza Jafari Yeganeh Sigrid Kufaas Brækkan Ellen Brodin John-Bjarne Hansen Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis Research and Practice in Thrombosis and Haemostasis biomarker cross-sectional studies deep vein thrombosis diagnosis microRNA patients |
| title | Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis |
| title_full | Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis |
| title_fullStr | Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis |
| title_full_unstemmed | Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis |
| title_short | Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis |
| title_sort | plasma microrna 145 5p as a diagnostic biomarker for acute deep vein thrombosis |
| topic | biomarker cross-sectional studies deep vein thrombosis diagnosis microRNA patients |
| url | http://www.sciencedirect.com/science/article/pii/S2475037924003662 |
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