Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration
Background. Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. Methods. Patients of CD/UC following between Dec 2014 and...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/1215035 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556218399326208 |
|---|---|
| author | Dawesh P. Yadav Saurabh Kedia Kumble Seetharama Madhusudhan Sawan Bopanna Sandeep Goyal Saransh Jain Naval K. Vikram Raju Sharma Govind K. Makharia Vineet Ahuja |
| author_facet | Dawesh P. Yadav Saurabh Kedia Kumble Seetharama Madhusudhan Sawan Bopanna Sandeep Goyal Saransh Jain Naval K. Vikram Raju Sharma Govind K. Makharia Vineet Ahuja |
| author_sort | Dawesh P. Yadav |
| collection | DOAJ |
| description | Background. Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. Methods. Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae. Visceral fat area (VFA), subcutaneous fat area (SCA), and visceral to subcutaneous fat ratio (VF/SC) were evaluated in CD patients on abdominal CT. Results. Lean mass in CD (n=44, mean age: 41.2±15.8 years, 73% males) was significantly lower than UC (n=53, mean age: 33.2±11.2 years, 68% males; 44.2±7.8 versus 48.3±8.4 Kg, p=0.01). In both UC/CD, disease severity was associated with nonsignificant decline in BMI (UC: 22.1±4.9 versus 20.2±3.2 versus 19.9±3.2 kg/m2, p=0.23; CD: 22.1±4.2 versus 19.9±2.3 versus 19.7±4.2 kg/m2, p=0.18) and fat mass (UC: 10.9±8.9 versus 8.1±5.9 versus 5.7±3.6 kg, p=0.14; CD: 11.2±7 versus 7.9±4.4 versus 7.2±5.9 kg, p=0.16), and disease duration was associated with significant decline in FFMI (p<0.05). In CD, disease severity was associated with nonsignificant decline in SCA and increase in VF/SC. Conclusions. CD patients have lower lean mass than UC. Body fat decreases with increasing disease severity and fat-free mass decreases with increasing disease duration in both UC/CD. |
| format | Article |
| id | doaj-art-c6864b6d34df4db0bae2c6b4af8613a0 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-c6864b6d34df4db0bae2c6b4af8613a02025-02-03T05:45:58ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972017-01-01201710.1155/2017/12150351215035Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and DurationDawesh P. Yadav0Saurabh Kedia1Kumble Seetharama Madhusudhan2Sawan Bopanna3Sandeep Goyal4Saransh Jain5Naval K. Vikram6Raju Sharma7Govind K. Makharia8Vineet Ahuja9Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, IndiaBackground. Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. Methods. Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae. Visceral fat area (VFA), subcutaneous fat area (SCA), and visceral to subcutaneous fat ratio (VF/SC) were evaluated in CD patients on abdominal CT. Results. Lean mass in CD (n=44, mean age: 41.2±15.8 years, 73% males) was significantly lower than UC (n=53, mean age: 33.2±11.2 years, 68% males; 44.2±7.8 versus 48.3±8.4 Kg, p=0.01). In both UC/CD, disease severity was associated with nonsignificant decline in BMI (UC: 22.1±4.9 versus 20.2±3.2 versus 19.9±3.2 kg/m2, p=0.23; CD: 22.1±4.2 versus 19.9±2.3 versus 19.7±4.2 kg/m2, p=0.18) and fat mass (UC: 10.9±8.9 versus 8.1±5.9 versus 5.7±3.6 kg, p=0.14; CD: 11.2±7 versus 7.9±4.4 versus 7.2±5.9 kg, p=0.16), and disease duration was associated with significant decline in FFMI (p<0.05). In CD, disease severity was associated with nonsignificant decline in SCA and increase in VF/SC. Conclusions. CD patients have lower lean mass than UC. Body fat decreases with increasing disease severity and fat-free mass decreases with increasing disease duration in both UC/CD.http://dx.doi.org/10.1155/2017/1215035 |
| spellingShingle | Dawesh P. Yadav Saurabh Kedia Kumble Seetharama Madhusudhan Sawan Bopanna Sandeep Goyal Saransh Jain Naval K. Vikram Raju Sharma Govind K. Makharia Vineet Ahuja Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration Canadian Journal of Gastroenterology and Hepatology |
| title | Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration |
| title_full | Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration |
| title_fullStr | Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration |
| title_full_unstemmed | Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration |
| title_short | Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration |
| title_sort | body composition in crohn s disease and ulcerative colitis correlation with disease severity and duration |
| url | http://dx.doi.org/10.1155/2017/1215035 |
| work_keys_str_mv | AT daweshpyadav bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT saurabhkedia bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT kumbleseetharamamadhusudhan bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT sawanbopanna bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT sandeepgoyal bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT saranshjain bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT navalkvikram bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT rajusharma bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT govindkmakharia bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration AT vineetahuja bodycompositionincrohnsdiseaseandulcerativecolitiscorrelationwithdiseaseseverityandduration |