A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases...
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Elsevier
2025-03-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580825000202 |
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| author | Fatmanur Yıldız Tyler W. LeBaron Duried Alwazeer |
| author_facet | Fatmanur Yıldız Tyler W. LeBaron Duried Alwazeer |
| author_sort | Fatmanur Yıldız |
| collection | DOAJ |
| description | Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hydroxyl radicals and peroxynitrite). H2 demonstrates numerous biologically therapeutic properties, including anti-inflammatory, antioxidant, anti-cancer, anti-stress, anti-apoptotic, anti-allergic effects, signaling molecule functions, regulation of redox balance, modulation of antioxidant enzyme gene expression, improvement of blood vessel function, down-regulation of pro-inflammatory cytokines, stimulation of energy metabolism, and protection of the nervous system. Experimental and clinical studies have shown the potential use of hydrogen nutrition therapy for ameliorating various diseases, including cardiovascular, respiratory, and metabolic disorders, as well as obesity, gastrointestinal disorders, and brain and nervous system disorders. The administration methods of hydrogen include inhalation, hydrogen-rich water, hydrogen-rich saline, hydrogen-rich eye drops, and hydrogen-rich bathing. Hydrogen nutritional therapy can be applied to different diseases, and it offers a natural alternative to chemical and radiation therapies. This review covers the different administration methods and the latest experimental and clinical research on the potential applications of H2 in nutritional therapy for different diseases. |
| format | Article |
| id | doaj-art-c6864703d868442eae9dd7f02c2b4ade |
| institution | OA Journals |
| issn | 2405-5808 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj-art-c6864703d868442eae9dd7f02c2b4ade2025-08-20T02:03:07ZengElsevierBiochemistry and Biophysics Reports2405-58082025-03-014110193310.1016/j.bbrep.2025.101933A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectivesFatmanur Yıldız0Tyler W. LeBaron1Duried Alwazeer2Research Center for Redox Applications in Foods (RCRAF), Iğdır University, 76000, Iğdır, Türkiye; Innovative Food Technologies Development, Application, and Research Center, Iğdır University, 76000, Iğdır, TürkiyeDepartment of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar City, UT, 84720, USA; Molecular Hydrogen Institute, Cedar City, UT, 84721, USAResearch Center for Redox Applications in Foods (RCRAF), Iğdır University, 76000, Iğdır, Türkiye; Innovative Food Technologies Development, Application, and Research Center, Iğdır University, 76000, Iğdır, Türkiye; Department of Nutrition and Dietetics, Faculty of Health Sciences, Iğdır University, 76000, Iğdır, Türkiye; Corresponding author. Innovative Food Technologies Development, Application, and Research Center, Iğdır University, 76000, Iğdır, Türkiye.Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hydroxyl radicals and peroxynitrite). H2 demonstrates numerous biologically therapeutic properties, including anti-inflammatory, antioxidant, anti-cancer, anti-stress, anti-apoptotic, anti-allergic effects, signaling molecule functions, regulation of redox balance, modulation of antioxidant enzyme gene expression, improvement of blood vessel function, down-regulation of pro-inflammatory cytokines, stimulation of energy metabolism, and protection of the nervous system. Experimental and clinical studies have shown the potential use of hydrogen nutrition therapy for ameliorating various diseases, including cardiovascular, respiratory, and metabolic disorders, as well as obesity, gastrointestinal disorders, and brain and nervous system disorders. The administration methods of hydrogen include inhalation, hydrogen-rich water, hydrogen-rich saline, hydrogen-rich eye drops, and hydrogen-rich bathing. Hydrogen nutritional therapy can be applied to different diseases, and it offers a natural alternative to chemical and radiation therapies. This review covers the different administration methods and the latest experimental and clinical research on the potential applications of H2 in nutritional therapy for different diseases.http://www.sciencedirect.com/science/article/pii/S2405580825000202Molecular hydrogenNutritional therapyDiseasesFree radicalsOxidative stress |
| spellingShingle | Fatmanur Yıldız Tyler W. LeBaron Duried Alwazeer A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives Biochemistry and Biophysics Reports Molecular hydrogen Nutritional therapy Diseases Free radicals Oxidative stress |
| title | A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives |
| title_full | A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives |
| title_fullStr | A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives |
| title_full_unstemmed | A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives |
| title_short | A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives |
| title_sort | comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases mechanisms and perspectives |
| topic | Molecular hydrogen Nutritional therapy Diseases Free radicals Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2405580825000202 |
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