Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology
This study investigated the batch stability of egg white peptides (EWPs) during the enzymatic hydrolysis process, and confirmed the potential application of four crucial four peptides inoxidative damage repair. The results revealed that different batches of EWPs had good stability relating to antiox...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/13/19/3148 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850185031697301504 |
|---|---|
| author | Siwen Lyu Ting Li Qi Yang Jingbo Liu Ting Zhang Ting Yu |
| author_facet | Siwen Lyu Ting Li Qi Yang Jingbo Liu Ting Zhang Ting Yu |
| author_sort | Siwen Lyu |
| collection | DOAJ |
| description | This study investigated the batch stability of egg white peptides (EWPs) during the enzymatic hydrolysis process, and confirmed the potential application of four crucial four peptides inoxidative damage repair. The results revealed that different batches of EWPs had good stability relating to antioxidant activity. With a similar sequence to confirmed antioxidant peptides, four EWPs (QMDDFE, WDDDPTD, DEPDPL, and FKDEDTQ) were identified withhigh repetition rates, and their potential to repair oxidative damage was investigated. Network pharmacology results showed that these four peptides could regulate the targets related to oxidative damage. Enrichment results demonstrated that these four peptides could influence the targets and pathways related to glutathione transferase activity (enrichment score: 148.0) and glutathione metabolism (<i>p</i> value: 9.22 × 10<sup>−10</sup>). This study could provide evidence for the batch stability of hydrolyzed prepared EWPs, and offer theoretical support for the development of antioxidant damage ingredients derived from foods. |
| format | Article |
| id | doaj-art-c6809fc3f38f4ba5a90b4b6eb439ce5a |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-c6809fc3f38f4ba5a90b4b6eb439ce5a2025-08-20T02:16:50ZengMDPI AGFoods2304-81582024-10-011319314810.3390/foods13193148Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network PharmacologySiwen Lyu0Ting Li1Qi Yang2Jingbo Liu3Ting Zhang4Ting Yu5Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, ChinaJilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, ChinaJilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, ChinaJilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, ChinaJilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, ChinaDepartment of Nutrition, The Second Hospital of Jilin University, Changchun 130041, ChinaThis study investigated the batch stability of egg white peptides (EWPs) during the enzymatic hydrolysis process, and confirmed the potential application of four crucial four peptides inoxidative damage repair. The results revealed that different batches of EWPs had good stability relating to antioxidant activity. With a similar sequence to confirmed antioxidant peptides, four EWPs (QMDDFE, WDDDPTD, DEPDPL, and FKDEDTQ) were identified withhigh repetition rates, and their potential to repair oxidative damage was investigated. Network pharmacology results showed that these four peptides could regulate the targets related to oxidative damage. Enrichment results demonstrated that these four peptides could influence the targets and pathways related to glutathione transferase activity (enrichment score: 148.0) and glutathione metabolism (<i>p</i> value: 9.22 × 10<sup>−10</sup>). This study could provide evidence for the batch stability of hydrolyzed prepared EWPs, and offer theoretical support for the development of antioxidant damage ingredients derived from foods.https://www.mdpi.com/2304-8158/13/19/3148egg white peptideshydrolysisantioxidant abilitynetwork pharmacologyoxidative related targets |
| spellingShingle | Siwen Lyu Ting Li Qi Yang Jingbo Liu Ting Zhang Ting Yu Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology Foods egg white peptides hydrolysis antioxidant ability network pharmacology oxidative related targets |
| title | Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology |
| title_full | Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology |
| title_fullStr | Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology |
| title_full_unstemmed | Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology |
| title_short | Potential Application of Egg White Peptides for Antioxidant Properties: Perspectives from Batch Stability and Network Pharmacology |
| title_sort | potential application of egg white peptides for antioxidant properties perspectives from batch stability and network pharmacology |
| topic | egg white peptides hydrolysis antioxidant ability network pharmacology oxidative related targets |
| url | https://www.mdpi.com/2304-8158/13/19/3148 |
| work_keys_str_mv | AT siwenlyu potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology AT tingli potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology AT qiyang potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology AT jingboliu potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology AT tingzhang potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology AT tingyu potentialapplicationofeggwhitepeptidesforantioxidantpropertiesperspectivesfrombatchstabilityandnetworkpharmacology |