Research progress on macrophages in cardiovascular diseases
Abstract Objective and design Cardiovascular diseases (CVD) are the leading causes of death worldwide, imposing a great burden on society. In recent years, macrophages have garnered widespread attention in CVD research. Macrophages are an important component of the body’s immune system, playing a cr...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-025-03541-4 |
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| _version_ | 1849235643125727232 |
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| author | Minyan Zhu Hongmei Zhou Lei Zhou Yaping Yang Rong Chen |
| author_facet | Minyan Zhu Hongmei Zhou Lei Zhou Yaping Yang Rong Chen |
| author_sort | Minyan Zhu |
| collection | DOAJ |
| description | Abstract Objective and design Cardiovascular diseases (CVD) are the leading causes of death worldwide, imposing a great burden on society. In recent years, macrophages have garnered widespread attention in CVD research. Macrophages are an important component of the body’s immune system, playing a critical role in clearing pathogens, repairing damaged tissues, and regulating inflammatory responses, have the potential to serve as a potential target for the treatment of CVD. Materials and methods To make up this review, studies covering Macrophage subtypes and signaling pathways, CVD were selected from the main medical databases. Conclusion In CVD, macrophages can differentiate into different phenotypes(M1, M2, M4, et al.) according to their microenvironment by their plasticity and heterogeneity, release different cytokines, are regulated by multiple signaling pathways(PI3K/Akt, TLR4, TGF-β/Smads, et al.), and play other functions in CVD. M1 initiates and maintains inflammation by secreting pro-inflammatory factors, and M2 participates in the regression of inflammation and tissue repair by secreting anti-inflammatory factors. Therefore, by regulating the signaling pathway, it reduces the aggregation of macrophages, promotes the polarization of macrophages to M2, or restores M1/M2 homeostasis to improve the inflammatory microenvironment and delay CVD progression. |
| format | Article |
| id | doaj-art-c67f3bb7a9a1409098fc9be780e7c5a1 |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-c67f3bb7a9a1409098fc9be780e7c5a12025-08-20T04:02:44ZengBMCJournal of Cardiothoracic Surgery1749-80902025-07-0120111210.1186/s13019-025-03541-4Research progress on macrophages in cardiovascular diseasesMinyan Zhu0Hongmei Zhou1Lei Zhou2Yaping Yang3Rong Chen4Department of Pharmacy, the First Affiliated Hospital of Soochow UniversityDepartment of Pharmacy, Taizhou People’s Hospital Affiliated to Nanjing Medical UniversityThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and PreventionDepartment of Pharmacy, the First Affiliated Hospital of Soochow UniversityDepartment of Pharmacy, the First Affiliated Hospital of Soochow UniversityAbstract Objective and design Cardiovascular diseases (CVD) are the leading causes of death worldwide, imposing a great burden on society. In recent years, macrophages have garnered widespread attention in CVD research. Macrophages are an important component of the body’s immune system, playing a critical role in clearing pathogens, repairing damaged tissues, and regulating inflammatory responses, have the potential to serve as a potential target for the treatment of CVD. Materials and methods To make up this review, studies covering Macrophage subtypes and signaling pathways, CVD were selected from the main medical databases. Conclusion In CVD, macrophages can differentiate into different phenotypes(M1, M2, M4, et al.) according to their microenvironment by their plasticity and heterogeneity, release different cytokines, are regulated by multiple signaling pathways(PI3K/Akt, TLR4, TGF-β/Smads, et al.), and play other functions in CVD. M1 initiates and maintains inflammation by secreting pro-inflammatory factors, and M2 participates in the regression of inflammation and tissue repair by secreting anti-inflammatory factors. Therefore, by regulating the signaling pathway, it reduces the aggregation of macrophages, promotes the polarization of macrophages to M2, or restores M1/M2 homeostasis to improve the inflammatory microenvironment and delay CVD progression.https://doi.org/10.1186/s13019-025-03541-4MacrophagesPhenotypesMechanism of actionCardiovascular diseases |
| spellingShingle | Minyan Zhu Hongmei Zhou Lei Zhou Yaping Yang Rong Chen Research progress on macrophages in cardiovascular diseases Journal of Cardiothoracic Surgery Macrophages Phenotypes Mechanism of action Cardiovascular diseases |
| title | Research progress on macrophages in cardiovascular diseases |
| title_full | Research progress on macrophages in cardiovascular diseases |
| title_fullStr | Research progress on macrophages in cardiovascular diseases |
| title_full_unstemmed | Research progress on macrophages in cardiovascular diseases |
| title_short | Research progress on macrophages in cardiovascular diseases |
| title_sort | research progress on macrophages in cardiovascular diseases |
| topic | Macrophages Phenotypes Mechanism of action Cardiovascular diseases |
| url | https://doi.org/10.1186/s13019-025-03541-4 |
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